{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:27:35Z","timestamp":1792056455423,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004103","name":"Landsp\u00edtali H\u00e1sk\u00f3lasj\u00fakrah\u00fas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003887","name":"International Myeloma Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003887","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["716677"],"award-info":[{"award-number":["716677"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011103","name":"Rann\u00eds","doi-asserted-by":"publisher","award":["2410755"],"award-info":[{"award-number":["2410755"]}],"id":[{"id":"10.13039\/501100011103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013352","name":"Tow Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Monoclonal gammopathy of undetermined significance (MGUS) is the asymptomatic precursor of multiple myeloma and related diseases but has also been associated with thrombosis. Prior studies have not been based on screened cohorts leading to bias. We assessed the risk of thrombosis in a cohort of 75\u2009422 individuals over 40\u2009years old who were screened for MGUS in Iceland. We also evaluated the association of M protein concentration with thrombotic risk. A total of 3668 participants had MGUS. After a median follow\u2010up of ~3.7\u2009years, 124 venous and 252 arterial thrombotic events (10.3 and 21.0 per 1000 person years respectively) were observed in the MGUS group, compared to 1509 and 3471 in the non\u2010MGUS group (6.0 and 13.8 per 1000 person years respectively). After adjusting for multiple confounders, MGUS was associated with an increased risk of venous thrombosis (hazard ratio [HR]\u2009=\u20091.43; 95% confidence interval [CI]: 1.19\u20131.73) but not arterial thrombosis (HR\u2009=\u20090.96; 95% CI: 0.87\u20131.13). M protein concentration was not associated with venous (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.72) or arterial (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.95) thrombosis. The findings show, in a screened cohort, that MGUS is associated with venous, but not arterial, thrombosis. Furthermore, they suggest that there is a subset of individuals with MGUS with subclinical monoclonal gammopathy of thrombotic significance.\n                  <\/jats:p>","DOI":"10.1111\/bjh.19957","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:34:06Z","timestamp":1735155246000},"page":"899-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Monoclonal gammopathy of undetermined significance and the risk of thrombotic events: Results from iStopMM, a prospective population\u2010based screening study"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2162-8414","authenticated-orcid":false,"given":"S\u00e6mundur","family":"R\u00f6gnvaldsson","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland"},{"name":"Landsp\u00edtali University Hospital  Reykjav\u00edk 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Thorir","family":"Oskarsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland"},{"name":"Landsp\u00edtali University Hospital  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbjorn","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Akureyri Hospital  Akureyri Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runolfur","family":"Palsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland"},{"name":"Landsp\u00edtali University Hospital  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur Skuli","family":"Indri\u00f0ason","sequence":"additional","affiliation":[{"name":"Landsp\u00edtali University Hospital  Reykjav\u00edk 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