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Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic sickle mice displayed significantly elevated titres of aPL\u2010 and SLE\u2010associated autoantibodies. We hypothesize that SCD may be a risk factor not only for the development of aPL but also more widespread autoimmunity.<\/jats:p>","DOI":"10.1111\/bjh.19972","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T05:14:44Z","timestamp":1735881284000},"page":"1213-1217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic lupus erythematosus\u2010associated autoantibodies in sickle cell disease: Spontaneous emergence in a patient and in transgenic sickle mice"],"prefix":"10.1111","volume":"206","author":[{"given":"Urshita","family":"Sinha","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Setty","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9leste","family":"Pilon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine McGill University &amp; 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