{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:13:13Z","timestamp":1748405593792,"version":"3.41.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Allogeneic hematopoietic stem cell transplantation (alloHSCT) remains an option for young and fit chronic lymphocytic leukaemia (CLL) patients with high\u2010risk disease features. However, allotransplanted patients are generally excluded from clinical trials, making data regarding the use of venetoclax after alloHSCT extremely rare. We report data from 7 CLL patients who received venetoclax after alloHSCT among 53 Italian centers. These patients underwent alloHSCT between 2006 and 2021 after failing chemoimmunotherapy (7\/7), ibrutinib (5\/7) and\/or idelalisib (1\/7). Of note, 3\/7 patients had already received venetoclax\u2010based therapy before alloHSCT. Post\u2010allo HSCT venetoclax treatment resulted safe, with adverse events not different from what reported in clinical trials. Importantly, no meaningful impact on graft versus host disease (GvHD) course was observed: 4\/7 patients with pre\u2010existing chronic GvHD had no exacerbation after venetoclax start, and only one patient developed GvHD during venetoclax therapy, that was managed as per standard clinical practice. Concerning efficacy, 5\/7 patients presented a clinical response to venetoclax, with two patients achieving an undetectable minimal residual disease. To our knowledge, this is the largest reported series of CLL patients treated with venetoclax after alloHSCT. In these heavily pretreated and high\u2010risk patients, previous alloHSCT did not compromise the feasibility of venetoclax therapy, that lacked unexpected toxicities and did not exacerbate GvHD.<\/jats:p>","DOI":"10.1111\/bjh.19976","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T07:38:20Z","timestamp":1736321900000},"page":"924-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Venetoclax therapy in chronic lymphocytic leukaemia patients relapsed after allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-9626","authenticated-orcid":false,"given":"Francesca","family":"Perutelli","sequence":"first","affiliation":[{"name":"University Division of Hematology, A.O.U. Citt\u00e0 Della Salute e Della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia","family":"Boccellato","sequence":"additional","affiliation":[{"name":"Azienda Santa Croce e Carle  Cuneo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Montalbano","sequence":"additional","affiliation":[{"name":"University Division of Hematology, A.O.U. Citt\u00e0 Della Salute e Della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences University of Torino  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioacchino","family":"Catania","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale Universit\u00e0 del Piemonte Orientale and S.C.D.U Ematologia Azienda Ospedaliero Universitaria Santi Antonio e Biagio e Cesare Arrigo  Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Deodato","sequence":"additional","affiliation":[{"name":"Department of Haematology Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-7901","authenticated-orcid":false,"given":"Anna Maria","family":"Frustaci","sequence":"additional","affiliation":[{"name":"Department of Haematology Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idanna","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Radiation Oncology and Hematology Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7393-1138","authenticated-orcid":false,"given":"Riccardo","family":"Moia","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliero\u2010Universitaria Maggiore Della Carit\u00e0  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-3775","authenticated-orcid":false,"given":"Francesca Maria","family":"Quaglia","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, Section of Biomedicine of Innovation, Department of Engineering for Innovative Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Quaresmini","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology University of Milan and ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Rivela","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Traslazionale Universit\u00e0 del Piemonte Orientale and S.C.D.U Ematologia Azienda Ospedaliero Universitaria Santi Antonio e Biagio e Cesare Arrigo  Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliero\u2010Universitaria Maggiore Della Carit\u00e0  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Krampera","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, Section of Biomedicine of Innovation, Department of Engineering for Innovative Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4527-4131","authenticated-orcid":false,"given":"Luca","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Radiation Oncology and Hematology Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"},{"name":"Section of Hematology, Department of Radiological and Hematological Sciences Catholic University of Sacred Heart  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology University of Milan and ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetto","family":"Bruno","sequence":"additional","affiliation":[{"name":"University Division of Hematology, A.O.U. 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