{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:53:16Z","timestamp":1790409196154,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001009","name":"Bristol Myers Squibb Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Most transplant\u2010ineligible patients present with multiple myeloma (MM) refractory to lenalidomide and\/or anti\u2010CD38 monoclonal antibody at first relapse and represent a difficult\u2010to\u2010treat population. The Intergroupe Francophone du My\u00e9lome phase 2 study iberdomide, ixazomib and dexamethasone (I2D) evaluated the oral triplet iberdomide, ixazomib and dexamethasone in MM patients aged \u226570\u2009years at first relapse (NCT04998786). Seventy patients were enrolled to receive iberdomide (1.6\u2009mg on day 1\u201321), ixazomib (3\u2009mg on day 1, 8, 15) and dexamethasone (20\u2009mg on day 1, 8, 15, 22 on cycle 1\u20132 and 10\u2009mg on day 1, 8, 15, 22 on cycle 3\u20136) (28\u2010day cycle) until disease progression. Median age was 76; 50% patients were frail according to the International Myeloma Working Group frailty score; 74% and 37% were refractory to lenalidomide and daratumumab respectively. With a median follow\u2010up of 14\u2009months, the overall response rate was 64%, including 36% very good partial response or better. The 12\u2010month progression\u2010free survival, duration of response and overall survival were 52%, 76% and 86% respectively. The most common (46%) grade 3\u20134 toxicity was neutropenia. Non\u2010haematological adverse events were mostly grade 1 or 2. Overall, I2D demonstrated a favourable risk\u2013benefit profile in elderly MM patients at first relapse, including in patients with lenalidomide and daratumumab refractory disease.<\/jats:p>","DOI":"10.1111\/bjh.19978","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T02:44:32Z","timestamp":1736131472000},"page":"1366-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Iberdomide, ixazomib and dexamethasone in elderly patients with multiple myeloma at first relapse"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-2575","authenticated-orcid":false,"given":"Cyrille","family":"Touzeau","sequence":"first","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire  Nantes France"},{"name":"CRCINA, INSERM, CNRS Universit\u00e9 d'Angers, Universit\u00e9 de Nantes  Nantes France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer (SIRIC) \u00ab ILIAD \u00bb INCA\u2010DGOS\u2010Inserm_12558  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-4170","authenticated-orcid":false,"given":"Xavier","family":"Leleu","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie, Centre Hospitalo\u2010Universitaire Universit\u00e9 de Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Tiab","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalier Departmental  La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Macro","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Perrot","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie, Centre Hospitalo\u2010Universitaire Institut Universitaire du Cancer Toulouse Oncopole, Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gay","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalier  Bayonne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Chateleix","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Moreau","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Karlin","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie H\u00f4pital Lyon Sud  Pierre\u2010Benite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Jacquet","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire de Nancy  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-711X","authenticated-orcid":false,"given":"Salomon","family":"Manier","sequence":"additional","affiliation":[{"name":"Maladies du Sang Centre Hospitalo\u2010Universitaire  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-5161","authenticated-orcid":false,"given":"Cyrille","family":"Hulin","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie, H\u00f4pital Haut\u2010L\u00e9v\u00eaque Centre Hospitalo\u2010Universitaire de Bordeaux  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Decaux","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Richez","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9833-3115","authenticated-orcid":false,"given":"Thomas","family":"Chalopin","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8536-7781","authenticated-orcid":false,"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie H\u00f4pital Saint Antoine  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Orsini\u2010Piocelle","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalier Regional  Annecy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Caillot","sequence":"additional","affiliation":[{"name":"H\u00e9matologie Clinique Centre Hospitalo\u2010Universitaire  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Sonntag","sequence":"additional","affiliation":[{"name":"H\u00e9matologie Clinique Institut de Canc\u00e9rologie de Strasbourg Europe  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Vignon","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie H\u00f4pital Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Bobin","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie, Centre Hospitalo\u2010Universitaire Universit\u00e9 de Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Avet\u2010Loiseau","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie, Centre Hospitalo\u2010Universitaire Institut Universitaire du Cancer Toulouse Oncopole, Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Jobert","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Recherche Clinique Centre Hospitalo\u2010Universitaire  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Planche","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Recherche Clinique Centre Hospitalo\u2010Universitaire  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-6106","authenticated-orcid":false,"given":"Jill","family":"Corre","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie, Centre Hospitalo\u2010Universitaire Institut Universitaire du Cancer Toulouse Oncopole, Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1780-8746","authenticated-orcid":false,"given":"Philippe","family":"Moreau","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Centre Hospitalo\u2010Universitaire  Nantes France"},{"name":"CRCINA, INSERM, CNRS Universit\u00e9 d'Angers, Universit\u00e9 de Nantes  Nantes France"},{"name":"Site de Recherche Int\u00e9gr\u00e9e sur le Cancer (SIRIC) \u00ab ILIAD \u00bb INCA\u2010DGOS\u2010Inserm_12558  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31594-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817249"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000528"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30152-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01921"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.add7574"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00290-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516282"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024013623"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.285916"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30756-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.7934"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-615187"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2400712"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003050\u20102"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403407"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00592-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30734-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405090"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303379"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213614"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204591"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02528-9"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2023.10.009"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T09:43:08Z","timestamp":1765791788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/bjh.19978"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19978","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,5]]},"assertion":[{"value":"2024-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}