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However, few studies have compared the outcome of AYA treated according to one or the other approaches. Among the 148 patients aged 15\u201325\u2009years, treated at Saint\u2010Louis Hospital for newly diagnosed HL between 2012 and 2018, 71 were treated according to an adult protocol and 77 were treated according to a paediatric one. The 5\u2010year overall survival (OS) and progression\u2010free survival (PFS) were, respectively, 100% and 85%, with no significant difference between treatment groups (85% in paediatric vs. 86% in adult, <jats:italic>p<\/jats:italic>\u2009=\u20090.7). Overall, the 5\u2010year PFS was 100% for early favourable stages and 78% for advanced stages. A higher risk of short\u2010term steroid and vincristine\u2010related toxicities was observed in paediatric regimen, whereas a higher risk of late toxicities was expected in adult regimen, due to higher anthracyclines, procarbazine, bleomycin and radiotherapy exposure. These results confirm the excellent outcome of AYA patients with HL, whatever the treatment strategies. They justify a tailor\u2010made therapeutic decision and highlight the importance of managing AYA patients in dedicated units with trained professionals.<\/jats:p>","DOI":"10.1111\/bjh.19985","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T03:09:59Z","timestamp":1736132999000},"page":"907-918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Should adolescents and young adults with Hodgkin lymphoma be treated as children or adults?"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-2801","authenticated-orcid":false,"given":"Lucille","family":"Lew\u2010Derivry","sequence":"first","affiliation":[{"name":"Pediatric Hematology and Oncology Department Sorbonne University APHP, A.Trousseau Hospital  Paris 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