{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:04:07Z","timestamp":1777892647817,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Patients with immune thrombocytopenia (ITP) suffer from an autoimmune bleeding disorder with an isolated low number of platelets. Platelets and megakaryocytes are targeted by the immune system, due to a loss of immune tolerance, via the action of platelet\u2010autoantibodies and\/or cytotoxic T cells. ITP is a highly variable disorder regarding the underlying biological mechanisms, disease trajectories and treatment responses. Predictive indicators are therefore strongly warranted. To analyze the predictive response to the thrombopoietin receptor agonist eltrombopag, in this issue of the British Journal of Haematology, Osuna\u2010Gomez and co\u2010workers research platelet\u2010leukocyte complexes in 38 ITP patients upon treatment with eltrombopag. Elevated platelet counts upon treatment with eltrombopag were associated with increased complexes of platelets bound to leucocytes. A higher percentage of monocytes bound to platelets, with an increased IL\u201010 production in monocytes, was found to be associated to a favorable clinical response to treatment with eltrombopag. Further validation is required but these findings reveal the potential of analyzing platelet\u2010monocyte complexes as a predictive indicator for the clinical response to eltrombopag in patients with ITP.<\/jats:p><jats:p>Commentary on: Osuna\u2010G\u00f3mez et\u00a0al. Interplay of leucocyte\u2010platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients. Br J Haematol 2025; 206:1200\u20101212.<\/jats:p>","DOI":"10.1111\/bjh.19991","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T09:44:27Z","timestamp":1735897467000},"page":"1253-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelets and monocytes: A dynamic duo aiding in the prediction of the clinical response to thrombopoietin receptor agonists in immune thrombocytopenia?"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-876X","authenticated-orcid":false,"given":"Rick","family":"Kapur","sequence":"first","affiliation":[{"name":"Sanquin Research, Department of Experimental Immunohematology Amsterdam and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6020016"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26045"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000612"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153403"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000812"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2016.04.010"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1624709"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-432575"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010097"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281717"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16459"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19779"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113235"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022738"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44321-024-00093-3"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.19991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T02:37:28Z","timestamp":1744339048000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.19991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/bjh.19991"],"URL":"https:\/\/doi.org\/10.1111\/bjh.19991","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"2024-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}