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However, studies focusing on paediatric patients with T\u2010ALL following haploidentical HSCT (haplo\u2010HSCT) are limited. We retrospectively identified a consecutive cohort comprising of 128 paediatric T\u2010ALL after haplo\u2010HSCT from 2642 consecutive ALL patients between January 2010 and June 2022. The 2\u2010year overall survival and leukaemia\u2010free survival were 67.77%\u2009\u00b1\u20094.21% and 66.34%\u2009\u00b1\u20093.82%, respectively, and the cumulative incidence of relapse (CIR) and non\u2010relapse mortality were 33.82%\u2009\u00b1\u20090.70% and 12.65%\u2009\u00b1\u20090.46% respectively. According to the multivariate Cox regression analysis, CD34 cells, minimal residual disease (MRD) \u22650.01% before HSCT, chronic graft\u2010versus\u2010host disease (cGvHD) and cytomegalovirus were associated with relapse (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). To develop a scoring system for stratifying patients, we combined the variables and stratified them into low (0\u20132 points) and high (3, 4) groups. Consequently, the 2\u2010year CIR in low and high groups were 23.76%\u2009\u00b1\u20091.83% and 48.22%\u2009\u00b1\u20092.42% (<jats:italic>p<\/jats:italic>\u2009=\u20090.009), respectively. Children with T\u2010ALL have poor long\u2010term survival, and haplo\u2010HSCT is a potent and safe treatment; however, the incidence of relapse is high. Eliminating pre\u2010HSCT MRD, guaranteeing sufficient CD34 cells infusion and the occurrence of cGvHD and cytomegalovirus reactivation may benefit from relapse.<\/jats:p>","DOI":"10.1111\/bjh.20007","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T05:54:04Z","timestamp":1740549244000},"page":"1165-1172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes and prognostic factors associated with relapse after haploidentical stem cell transplantation for paediatric T\u2010cell acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"206","author":[{"given":"Chen","family":"Zhao","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2555-076X","authenticated-orcid":false,"given":"Meng\u2010Yu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Bai","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan\u2010Hua","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Suo","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng\u2010Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Dong","family":"Mo","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan\u2010Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Disease Peking University 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