{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:31:53Z","timestamp":1793395913765,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This nationwide cohort study provides a comprehensive overview of maternal and perinatal outcomes associated with sickle cell disease (SCD) during pregnancy. Using the French national health database, all singleton pregnancy\u2010related hospital discharges from 2013 to 2020 in women aged 15\u201355 (<jats:italic>n<\/jats:italic>\u2009=\u20095\u2009752\u2009080) were selected. Of these, 1022 births were to women with SCD, 308 of whom were on long\u2010term treatment, that is, hydroxyurea (HU) and\/or transfusion programme. Pregnancies with SCD were more likely to involve pre\u2010eclampsia (9.6% vs. 1.7%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), pulmonary embolism (0.70% vs. 0.02%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), caesarean sections (52.8% vs. 18.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and postpartum haemorrhage (8.3% vs. 4.1%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to pregnancies without SCD. Preterm birth (&lt;37\u2009weeks) was much more common in women with SCD (28.5% vs. 5.6%). Infants born to women with SCD faced greater adverse neonatal outcomes (22.4% vs. 8.0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Although untreated SCD was linked to fewer complications than long\u2010term treated SCD, both conditions presented greater risks compared with pregnancies without SCD. Unexpectedly, babies born to women with SCD had a higher incidence of congenital abnormalities (6.3% vs. 3.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), not attributed to HU use. Overall, despite advances in SCD management, pregnancy in SCD remains a high\u2010risk condition, for both mothers and babies.<\/jats:p>","DOI":"10.1111\/bjh.20009","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T04:10:21Z","timestamp":1740197421000},"page":"1218-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Maternal and perinatal outcomes of sickle cell disease in pregnancy: A nationwide study in France"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-2422","authenticated-orcid":false,"given":"Alice","family":"Corsia","sequence":"first","affiliation":[{"name":"Biotherapy Department and Clinical Investigation Center, Assistance Publique H\u00f4pitaux de Paris H\u00f4pital Universitaire Necker\u2010Enfants Malades  Paris France"},{"name":"Centre de r\u00e9f\u00e9rence des syndromes dr\u00e9panocytaires majeurs, service de 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