{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:48:33Z","timestamp":1772070513353,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mature B\u2010cell acute lymphocytic leukaemia (B\u2010ALL) is distinguished from B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL) by the arbitrariness of the 25% cut\u2010off, and given that the percentage of bone marrow (BM) blasts can vary according to site of aspirate, we refrained from differentiating mature B\u2010ALL from B\u2010NHL with BM infiltration. A total of 156 patients from the Chinese Children Cancer Group with BM blasts of more than 5% and consistent with immunophenotypic features of mature B cells were included in this study. The 2\u2010year progression\u2010free survival, 2\u2010year event\u2010free survival and 2\u2010year overall survival were 76.6\u2009\u00b1\u20093.6%, 69.7\u2009\u00b1\u20093.7% and 80.1\u2009\u00b1\u20093.3% respectively. Central nervous system (CNS) involvement, serum ferritin levels higher than four times normal and rituximab no more than two doses were associated with lower PFS. Male, bulky disease and head\/neck region involvement were associated with higher rate of CNS invasion. We performed an integrative transcriptomic characterization of 36 cases. Structure variant included <jats:italic>IG::MYC<\/jats:italic>, <jats:italic>IGH::CACS11<\/jats:italic>, <jats:italic>MEF2D::BCL9<\/jats:italic>, <jats:italic>IGH::VPS53<\/jats:italic> and <jats:italic>ACIN1::NUTM1<\/jats:italic>. SNV analysis uncovered driver variations affecting 10 recurrently mutated genes including <jats:italic>ID3<\/jats:italic>, <jats:italic>TP53<\/jats:italic>, <jats:italic>MYC<\/jats:italic>, <jats:italic>ARID1A<\/jats:italic>, <jats:italic>SMARCA4<\/jats:italic>, <jats:italic>DDX3X<\/jats:italic>, <jats:italic>CCND3<\/jats:italic>, <jats:italic>RHOA<\/jats:italic>, <jats:italic>SMARCB1<\/jats:italic>, <jats:italic>FOXO1<\/jats:italic> and <jats:italic>GNA13<\/jats:italic>. Mature B\u2010ALL\/B\u2010NHL with BM involvement was a heterogeneous group of malignancies in both clinical features and genetic alternations. Genetics analysis was helpful for making accurate diagnoses and guiding appropriate therapeutic strategies.<\/jats:p>","DOI":"10.1111\/bjh.20011","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T07:39:47Z","timestamp":1739864387000},"page":"1149-1159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and molecular characteristics of paediatric mature B\u2010cell acute lymphocytic leukaemia and non\u2010Hodgkin lymphoma with bone marrow involvement: A joint study between the CCCG leukaemia and lymphoma groups"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-3360","authenticated-orcid":false,"given":"Jie","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oncology, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai 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