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However, refractory or relapsed (R\/R) B\u2010NHL remains extremely difficult to cure (&lt;30%). This retrospective study of 45 patients with R\/R B\u2010NHL reflects the limited benefit associated with reintroducing rituximab in second\u2010line strategies, the importance of achieving complete remission before stem cell transplantation and the potential role of\n                    <jats:italic>TP53<\/jats:italic>\n                    as a biomarker in R\/R B\u2010NHL.\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations were identified in 44% of tumours and associated with a worse 3\u2010year overall survival (15% vs. 80%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.048).\n                  <\/jats:p>","DOI":"10.1111\/bjh.20012","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:55:05Z","timestamp":1741719305000},"page":"1390-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive analysis of relapsed\u2010refractory mature B\u2010cell non\u2010Hodgkin lymphoma in children and adolescents"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-2470","authenticated-orcid":false,"given":"Sara","family":"Mato","sequence":"first","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Universitat de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4436-6861","authenticated-orcid":false,"given":"Lorenzo","family":"Carit\u00e0","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-0057","authenticated-orcid":false,"given":"Ariadna","family":"Colmenero","sequence":"additional","affiliation":[{"name":"Institut 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