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We report the UK experience of daratumumab\u2013bortezomib\u2013thalidomide\u2013dexamethasone for the first\u2010line treatment of AL amyloidosis. Consecutive patients with a new diagnosis of systemic AL between 2021 and 2023 were retrospectively reviewed from the UK National Amyloidosis Centre database. One hundred and two patients were included; median age was 61\u2009years, involved free light\u2010chain concentration 234\u2009mg\/L, 65% had cardiac and 63% renal involvement with modified Mayo stage I\/II\/IIIa\/IIIb in 24%\/36%\/21% and 19% respectively. A median of 6\u2009cycles was delivered. By intention\u2010to\u2010treat analysis, best haematological overall response rate was 97%: complete response at 65%, very good partial response at 22%, partial response at 11% and no response at 3%. At 6\u2010 and 12\u2010month time points from treatment initiation, best cardiac response rates were 39% and 45%, respectively, for evaluable patients. At a median duration of 18\u2009months follow\u2010up, the estimated 1\u2010year overall survival was 89% (95% confidence interval [CI] 81\u201394) and treatment\u2010free survival\/death was 82% (95% CI 73\u201389). We demonstrate efficacy in this real\u2010world population with comparable results to the gold standard, daratumumab\u2013bortezomib\u2013cyclophosphamide\u2013dexamethasone.<\/jats:p>","DOI":"10.1111\/bjh.20021","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:17:22Z","timestamp":1740129442000},"page":"1141-1148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes of daratumumab\u2013bortezomib\u2013thalidomide\u2013dexamethasone in treatment\u2010naive systemic AL amyloidosis"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-7828","authenticated-orcid":false,"given":"Jahanzaib","family":"Khwaja","sequence":"first","affiliation":[{"name":"University College London Hospital  London UK"},{"name":"National Amyloidosis Centre Royal Free London Hospital  London 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