{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:49:00Z","timestamp":1793227740391,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Iron\u2010refractory iron deficiency anaemia (IRIDA) is a rare hereditary microcytic anaemia characterized by partial or complete resistance to oral iron supplementation, caused by elevated plasma hepcidin levels resulting from pathogenic variants in the\n                    <jats:italic>TMPRSS6<\/jats:italic>\n                    gene. Although intravenous iron supplementation is often effective, patient responses can vary significantly due to various factors, and potential side effects of this treatment remain unclear. Additionally, evidence\u2010based international guidelines for diagnosing and managing IRIDA are lacking. This review aims to provide patient\u2010tailored treatment strategies, informed by case studies and expert opinion, to address the specific therapeutic needs of both children and adults with IRIDA.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20030","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T04:59:41Z","timestamp":1740200381000},"page":"1067-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["How I treat iron\u2010refractory iron deficiency anaemia\u2014\n                    <i>An expert opinion\u2010based treatment guidance for children and adults<\/i>"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5036-8554","authenticated-orcid":false,"given":"V.","family":"Hoving","sequence":"first","affiliation":[{"name":"Department of Haematology Radboud University Medical Center  Nijmegen the\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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