{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:29:23Z","timestamp":1788262163452,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015022","name":"S\u00e4chsische Landesbibliothek \u2013 Staats- und Universit\u00e4tsbibliothek Dresden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Imatinib (IMA) therapy for paediatric chronic myeloid leukemia (pCML) requires age\u2010dependent dose adjustments. Assessment of therapeutic drug monitoring (TDM) under \u2018real\u2010world\u2019 conditions was performed. Collection of blood and TDM\u2010relevant data, calculation of individual dosage exposure, measurement of plasma\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    (IMA, Nor\u2010IMA) by HPLC\/MS\u2010MS and recording of adverse event (AE). Two hundred and forty\u2010six specimens from 66 patients were analysed. Individual median IMA dosage exposure was 253\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (range: 128\u2013504). Children &lt;13\u2009years received a median of 43\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    more than older patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Median\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    of IMA and Nor\u2010IMA was 1017\u2009ng\/mL (range: 51\u20133976) and 269\u2009ng\/mL (range: 21\u2013981), respectively, correlating significantly with the prescribed dose. At 5\/246 visits, non\u2010adherence was confirmed by very low IMA\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    in 3\/66 patients, all \u226513\u2009years old. Correlation of IMA\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    &gt;1000\u2009ng\/mL with achieving OMR demonstrated in each 63% (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200924\/37,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200927\/43, respectively) patients at months 3 and 6. In the cohort with lower levels, only 23% and 50%, respectively, achieved these milestones. This difference was significant only at month 3. Of 66 patients, 30 reported 125 AEs with gastrointestinal and musculoskeletal as leading complaints. In 9.3% of AEs, the correlated IMA\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    was \u22653000\u2009ng\/mL. TDM is a simple and rapid additional tool for managing pCML under \u2018real\u2010world conditions\u2019.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20047","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:05:22Z","timestamp":1741727122000},"page":"1397-1405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic drug monitoring of imatinib in paediatric chronic myeloid leukaemia: Data from a real\u2010world setting"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9522-8838","authenticated-orcid":false,"given":"Meinolf","family":"Suttorp","sequence":"first","affiliation":[{"name":"Pediatric Hemato\u2010Oncology, Medical Faculty Technical University Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Sembill","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine University Hospital Erlangen  Erlangen Germany"},{"name":"Comprehensive Cancer Center Erlangen\u2010EMN (CCC ER\u2010EMN)  Erlangen Germany"},{"name":"Bavarian Cancer Research Center (BZKF)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Lensker","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine University Hospital Erlangen  Erlangen Germany"},{"name":"Pharmacy Department University Hospital Erlangen and Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine University Hospital Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine University Hospital Erlangen  Erlangen Germany"},{"name":"Bavarian Cancer Research Center (BZKF)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-7271","authenticated-orcid":false,"given":"Axel","family":"Karow","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine University Hospital Erlangen  Erlangen Germany"},{"name":"Comprehensive Cancer 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