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GPIb\u03b1, an important autoantigen in ITP, is notably linked to refractoriness, highlighting the need for novel treatments. We assessed CD19 chimeric antigen receptor (CAR)\u2010T cell therapy's potential in a modified murine model targeting GPIb\u03b1. CD19 CAR\u2010T cell infusion accelerated platelet count recovery compared to the control group, effectively depleted CD19\n                    <jats:sup>+<\/jats:sup>\n                    B cells and CD138\n                    <jats:sup>+<\/jats:sup>\n                    plasma cells, and markedly reduced anti\u2010GPIb\u03b1 autoantibodies in\u00a0vivo. In\u00a0vitro CD19 CAR\u2010T cells reduced both plasma cells and B cells in the spleens of mice and ITP patients. CD19 CAR\u2010T cell therapy significantly altered T\u2010cell subsets, increasing regulatory T cells, T helper 1 and T helper 17 populations, suggesting a role in modulating the immune response for sustained ITP remission. Monitoring of body\/spleen weights and temperature showed no significant cytokine release syndrome, indicating a favourable safety profile. These promising results support the potential of CD19 CAR\u2010T cell therapy as a novel treatment option for refractory ITP, particularly in GPIb\u03b1\u2010positive autoantibody patients. Further clinical studies are warranted to assess the safety and efficacy of this approach in human patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20061","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T12:00:12Z","timestamp":1743249612000},"page":"1430-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["CD19 chimeric antigen receptor\u2010T cell therapy in murine immune thrombocytopenia"],"prefix":"10.1111","volume":"206","author":[{"given":"Fengjiao","family":"Han","sequence":"first","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University  Jinan 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