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We report the clinical outcome of four multirefractory\/advanced VEXAS patients treated with acute myeloid leukaemia\u2010like therapeutic approaches. All patients responded to inflammatory\/haematological VEXAS\u2010related features, which were associated with measurable residual disease response (partial or complete). Prospective studies evaluating new and effective therapeutic strategies in order to reduce clonal burden in VEXAS patients are warranted.<\/jats:p>","DOI":"10.1111\/bjh.20067","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T03:35:13Z","timestamp":1744083313000},"page":"1683-1688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myeloid neoplasm inspired intensive therapy in <scp>VEXAS<\/scp> syndrome: A single\u2010centre experience"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-8657","authenticated-orcid":false,"given":"Ma\u00ebl","family":"Heiblig","sequence":"first","affiliation":[{"name":"Service d'h\u00e9matologie Clinique, H\u00f4pital Lyon Sud Hospices Civils de Lyon  Lyon France"},{"name":"Centre Hospitalier Lyon Sud and Universit\u00e9 Claude Bernard Lyon\u20101  Pierre\u2010B\u00e9nite France"},{"name":"Team Lymphoma 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