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Given the less strict Human Leukocyte Antigen match criteria, CB grafts extend access to transplant for underserved populations, who may not have suitable related or unrelated donors readily available. CB clinical outcomes are steadily improving in experienced transplant centres (TC); furthermore, the robust graft\u2010versus\u2010leukaemia effect is particularly beneficial for patients with aggressive leukaemia, making CB the \u2018graft of choice\u2019 for these groups. However, many TC have abandoned CB transplants (CBT) because of high cost, medical complexity and (now) lack of expertise. This Nutshell review discusses the role of CB in transplantation and the ongoing efforts to optimize CBT practices and improve CB utilization.<\/jats:p>","DOI":"10.1111\/bjh.20076","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T03:23:45Z","timestamp":1745551425000},"page":"1312-1314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cord blood transplants: Advancing leukaemia treatments and addressing health disparities"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-1069","authenticated-orcid":false,"given":"Andromachi","family":"Scaradavou","sequence":"first","affiliation":[{"name":"Associate Attending, Stem Cell Transplantation and Cellular Therapies, MSK Kids Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17297"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szad072"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008572"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17468"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018028662"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00184"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012385"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003371"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602074"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02497-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.10.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009253"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018025908"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007535"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18530"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01474-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1221782"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-654780"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017010827"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910607"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011719"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010599"},{"key":"e_1_2_8_25_1","unstructured":"Available from:https:\/\/www.cordbloodnetwork.org"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.20076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T09:42:51Z","timestamp":1765791771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.20076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/bjh.20076"],"URL":"https:\/\/doi.org\/10.1111\/bjh.20076","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"2024-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}