{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:06:03Z","timestamp":1791349563928,"version":"4.3.1"},"reference-count":74,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971994"],"award-info":[{"award-number":["81971994"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172335"],"award-info":[{"award-number":["82172335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91846103"],"award-info":[{"award-number":["91846103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2020C03032"],"award-info":[{"award-number":["2020C03032"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. The mechanism of ITP is complex and remains incompletely understood, but loss of self\u2010tolerance and immune cell dysfunction are associated with this disease. Platelet factor 4 (PF4) is released by activated platelets and has several other biological functions, including leucocyte activation and differentiation. In this study, we detected significant upregulation of PF4 expression in the serum and spleen of ITP mice and the expansion of CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    type I follicular helper T (Tfh1) cells. An in\u00a0vitro study revealed that the administration of recombinant PF4 protein in combination with IL\u201012 synergistically promoted the differentiation of na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells into Tfh1 cells through the STAT1 pathway. In this study, we identified the role of PF4 in activating Tfh1 cell differentiation and expansion and eventually promoting the pathogenesis of ITP.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20090","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:24:50Z","timestamp":1748337890000},"page":"259-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>PF4<\/scp>\n                    promotes\n                    <scp>CXCR3<\/scp>\n                    <sup>+<\/sup>\n                    Tfh1 cell differentiation through\n                    <scp>STAT1<\/scp>\n                    in mouse immune thrombocytopenia"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-5492","authenticated-orcid":false,"given":"Lei","family":"Hai","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-671X","authenticated-orcid":false,"given":"Jue","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1810479"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012541"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2021.1995347"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000447"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072212"},{"issue":"3","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3324\/haematol.2018.204040","article-title":"Human leukocyte antigen\u2010G upregulates immunoglobulin\u2010like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia","volume":"106","author":"Li X","year":"2021","journal-title":"Haematologica"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1050285"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO\u201014\u201009\u20100043"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702231168142"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563445"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.11.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.260298"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.14075"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315445"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-021-00318-2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2020.1776079"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-847624"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3078"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24395"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10051004"},{"key":"e_1_2_10_22_1","first-page":"0236","article-title":"Desialylated platelet clearance in the liver is a novel mechanism of systemic immunosuppression","volume":"6","author":"Li J","year":"2023","journal-title":"Research (Wash D C)"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.324167"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1178792"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1936479"},{"issue":"9","key":"e_1_2_10_26_1","first-page":"694","article-title":"The cytokines (IFN\u2010gamma, IL\u20102, IL\u20104, IL\u201010, IL\u201017) and Treg cytokine (TGF\u2010beta1) levels in adults with immune thrombocytopenia","volume":"69","author":"Ma L","year":"2014","journal-title":"Pharmazie"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101335"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56365-3"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218011"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50614-1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101400"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1054472"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03625-x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418549112"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413310"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.7243\/2053\u2010213X\u20101\u20103"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7310002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9487-9_2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529963"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03079"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216690"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024013317"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01401-z"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18773"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8737"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2023.101112"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12480"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024012995"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112131"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01089-8"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.08.033"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000280413"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-120419-022408"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.08.015"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.742061"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03115-2"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052509"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2016.80"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121766"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123397"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.042"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747034"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102144"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144654"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.04.011"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800876"},{"issue":"6","key":"e_1_2_10_67_1","article-title":"Immune thrombocytopenia: recent advances in pathogenesis and treatments","volume":"5","author":"Audia S","year":"2021","journal-title":"Hema"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-784975"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0413-3"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-244772"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27445"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12079"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-635417"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1530s113"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156684"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.20090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.20090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.20090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:20:45Z","timestamp":1771035645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.20090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/bjh.20090"],"URL":"https:\/\/doi.org\/10.1111\/bjh.20090","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"assertion":[{"value":"2024-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}