{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:12:01Z","timestamp":1792005121732,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Burkitt lymphoma (BL) is a challenging cancer to treat in resource\u2010limited settings. We retrospectively analysed 85 BL children \u226414\u2009years, treated during 2007\u20132017. Median age was 6.5 (2\u201312)\u2009years. Group A, B and C disease was seen in 22%, 48% and 30% respectively. Advanced disease was seen in 78% (stage III 33, stage IV 25). Six children had stage I and 21 had stage II disease. The commonest primary site was the abdomen (56%). Ten children had central nervous system (CNS) and 22 had marrow involvement. Treatment protocols included cyclophosphamide, oncovin, methotrexate, prednisolone (COMP) (United Kingdom Childhood Cancer Study Group) for group A and Multi Centre Protocol 842 (MCP 842) (2007\u20132008)\/modified Lymphomes Malins de Burkitt (LMB) 96 (2009\u20132017) for group B and C disease. Seventeen children developed tumour lysis syndrome (TLS). Twenty\u2010two children (25%) expired, six from TLS, four from infection and 12 due to disease. Median follow\u2010up was 8.6 (4\u201315) years. Four\u2010year event\u2010free survival (EFS) and overall survival (OS) were 72.9% and 74.1% respectively. Four\u2010year OS for group A, B, C and stage I, II, III, IV was 100%, 73.2%, 56% (<jats:italic>p<\/jats:italic>\u2009=\u20090.005) and 100%, 90.5%, 72.7%, 56% (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) respectively. Advanced disease and TLS were significant predictors of inferior EFS on multivariate analysis. We could achieve reasonably good survival in resource\u2010limited settings with judicious use of resources like single\u2010dose rasburicase and modified dose methotrexate.<\/jats:p>","DOI":"10.1111\/bjh.20093","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:55:20Z","timestamp":1745297720000},"page":"1710-1718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resource\u2010adapted strategies in the management of paediatric Burkitt lymphoma in low\u2010 and middle\u2010income country setting and outcomes: An Indian centre experience"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7258-6659","authenticated-orcid":false,"given":"Garima","family":"Nirmal","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-8391","authenticated-orcid":false,"given":"Priyakumari","family":"Thankamony","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha A.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pathology Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjusha","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binitha","family":"Rajeswari","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Guruprasad","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. R.","family":"Prasanth","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya Mary","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Pathology Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M. Jagathnath","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Regional Cancer Centre  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.23187"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD\u20102006\u201007\u2010036673"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.6376"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJH.15785"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/PBC.21452"},{"key":"e_1_2_11_7_1","first-page":"332","article-title":"Classification, staging and end results of treatment of childhood non\u2010Hodgkin's lymphomas dissimilarities from lymphomas in adults","volume":"7","author":"Murphy SB","year":"1980","journal-title":"Semin Oncol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJH.13040"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/PBC.28682"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806\u20109282.66.1.25"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/PBC.22047"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJH.12434"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.V97.11.3370"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426\u2010200411000\u201000012"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426\u2010200407000\u201000014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJMPO.IJMPO_42_16"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1743\u20107563.2009.01264.X"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1519810"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1915315"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.30576"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.3369"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/S\u20102008\u20101046610"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516\u20108484.20120093"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/PBC.27401"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11096\u2010020\u201001144\u20108"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ANNONC\/MDR490"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.20093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T08:24:19Z","timestamp":1760689459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.20093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/bjh.20093"],"URL":"https:\/\/doi.org\/10.1111\/bjh.20093","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]},"assertion":[{"value":"2024-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}