{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:04:15Z","timestamp":1792760655150,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010806","name":"Amgen Nederland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPOC22\u201003\/L2699"],"award-info":[{"award-number":["PPOC22\u201003\/L2699"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Sustained remissions off\u2010treatment (SROTs) after tapering of thrombopoietin receptor agonists (TPO\u2010RAs) have been reported in 15%\u201350% of patients with immune thrombocytopenia (ITP). The STIP (Stop TPO\u2010Receptor Agonist in ITP Patients) study is a prospective trial aimed to investigate the clinical effects of romiplostim tapering. Adult patients (22\/40) with ITP \u22653\u2009months received romiplostim for 1\u2009year, were tapered and followed for 1\u2009year. Anti\u2010platelet antibodies (APAs), TPO levels and indium\u2010111 platelet scintigraphy were assessed before, during and after romiplostim. Censored survival analysis showed that the probability of SROT at 1\u2009year after tapering was 23.6% (95% confidence interval: 11.0%\u201350.5%). Patients with SROT had higher platelet levels on romiplostim (median: 332.5 vs. 84.5\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L) and lower romiplostim doses at the start of tapering (median: 1.0 vs. 4.5\u2009\u03bcg\/kg) compared to those with a non\u2010sustained response (NSR). APAs were detected in 8\/25 patients at baseline, of which 5 showed a substantial decrease during romiplostim. The indium\u2010111 scan revealed an improved platelet survival at the start of tapering for 50% of patients with SROT (2\/4, missing\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091) versus none with an NSR (0\/14, missing\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093). Overall, the STIP study demonstrated a probability of SROT of 23.6% in a diverse and largely chronic group of adult patients with ITP.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20100","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:00:01Z","timestamp":1747630801000},"page":"1743-1753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The \u2018Stop TPO\u2010RA in ITP Patients\u2019 study: Clinical and immune modulatory effects of romiplostim tapering"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-2687","authenticated-orcid":false,"given":"Vivianne S.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Hematology Haga Teaching Hospital  The Hague The Netherlands"},{"name":"Sanquin Blood Supply Foundation, Department Research, and Amsterdam UMC location University of Amsterdam, Landsteiner Laboratory  Amsterdam The\u00a0Netherlands"},{"name":"Department of Hematology Leiden University Medical Center (LUMC)  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufia N.","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Hematology Haga Teaching Hospital  The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Netelenbos","sequence":"additional","affiliation":[{"name":"Department of Hematology Haga Teaching Hospital  The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina S.","family":"Kartachova","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Haga Teaching Hospital  The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-6033","authenticated-orcid":false,"given":"Roger E. G.","family":"Schutgens","sequence":"additional","affiliation":[{"name":"Center for Benign Hematology, Thrombosis and Hemostasis, Van Creveldkliniek UMC Utrecht and University Utrecht  Utrecht The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Hematology Isala  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Westerweel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Albert Schweitzer Hospital  Dordrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap J.","family":"Zwaginga","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center (LUMC)  Leiden The Netherlands"},{"name":"Medical Affairs Sanquin Blood Supply Foundation  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Hofstede\u2010van Egmond","sequence":"additional","affiliation":[{"name":"Immunohematology Diagnostics Sanquin Diagnostic Services  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-876X","authenticated-orcid":false,"given":"Rick","family":"Kapur","sequence":"additional","affiliation":[{"name":"Sanquin Blood Supply Foundation, Department Research, and Amsterdam UMC location University of Amsterdam, Landsteiner Laboratory  Amsterdam The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-0525","authenticated-orcid":false,"given":"Masja","family":"de Haas","sequence":"additional","affiliation":[{"name":"Medical Affairs Sanquin Blood Supply Foundation  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-0446","authenticated-orcid":false,"given":"Leendert","family":"Porcelijn","sequence":"additional","affiliation":[{"name":"Immunohematology Diagnostics Sanquin Diagnostic Services  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Schipperus","sequence":"additional","affiliation":[{"name":"Medical Affairs Sanquin Blood Supply Foundation  Amsterdam The 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