{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:42:26Z","timestamp":1794004946864,"version":"4.8.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Luspatercept has been approved for the treatment of anaemia in transfusion\u2010dependent (TD) patients with lower risk (LR) myelodysplastic syndromes (MDS) after erythroid\u2010stimulated agent (ESA) failure, according to the results of the MEDALIST trial. In this multicentre retrospective study, we report efficacy and safety data of luspatercept administered in 98 TD LR\u2010MDS patients after ESA failure. The percentage of patients that stopped luspatercept due to adverse events was comparable to that reported in the MEDALIST study. Furthermore, we observed that 44.3% patients who had completed 24\u2009weeks of follow\u2010up achieved transfusion independence lasting longer than 8\u2009weeks, compared to 38% in the MEDALIST trial. These positive results may be attributed to the inclusion of patients with lower transfusion needs in our study. All responses were observed within 8\u2009months since luspatercept onset and many were long\u2010lasting, even in the high\u2010transfusion burden patient group. In addition, response to luspatercept and the presence of less than two mutations independently predicted for longer overall survival. Overall, our results confirm luspatercept's safety and efficacy in TD LR\u2010MDS patients who have experienced ESA failure in a real\u2010world setting.<\/jats:p>","DOI":"10.1111\/bjh.20102","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:05:08Z","timestamp":1746497108000},"page":"101-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Real\u2010life experience of luspatercept in transfusion\u2010dependent lower risk myelodysplastic syndrome patients"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9234-7073","authenticated-orcid":false,"given":"Anthi","family":"Bouchla","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine and Research Institute, Hematology Unit, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-837X","authenticated-orcid":false,"given":"Sotirios G.","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine and Research Institute, Hematology Unit, Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kotsianidis","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of Alexandroupolis Democritus University of Thrace Medical School  Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-5944","authenticated-orcid":false,"given":"Panagiotis","family":"Diamantopoulos","sequence":"additional","affiliation":[{"name":"Hematology Unit, First Department of Internal Medicine, Laikon General Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8883-8208","authenticated-orcid":false,"given":"Eleni","family":"Gavriilaki","sequence":"additional","affiliation":[{"name":"Hematology Department BMT Unit G. Papanicolaou Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Bouronikou","sequence":"additional","affiliation":[{"name":"Department of Hematology University Hospital of Larissa  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-3473","authenticated-orcid":false,"given":"Argiris","family":"Symeonidis","sequence":"additional","affiliation":[{"name":"Department of Hematology University General Hospital of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Zikos","sequence":"additional","affiliation":[{"name":"Department of Hematology Aghios Andreas General Hospital  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Cetiner","sequence":"additional","affiliation":[{"name":"Acibadem MAA University School of Medicine Department of Hematology  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthymia","family":"Vlachaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Second Department of Internal Medicine, Hippokration General Hospital Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akrivi","family":"Kostourou","sequence":"additional","affiliation":[{"name":"Hematology Department Pammakaristos Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Galanopoulos","sequence":"additional","affiliation":[{"name":"Department of Hematology Gennimatas General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4408-5646","authenticated-orcid":false,"given":"Eleftheria","family":"Hatzimichael","sequence":"additional","affiliation":[{"name":"Department of Haematology, Faculty of Medicine School of Health Sciences University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet\u2010Christina","family":"Vervesou","sequence":"additional","affiliation":[{"name":"Department of Hematology Errikos Dunant Hospital Center  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem Civriz","family":"Bozda\u011f","sequence":"additional","affiliation":[{"name":"Department of Hematology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora\u2010Athina","family":"Viniou","sequence":"additional","affiliation":[{"name":"Hematology Department, Medical Centre of Athens Faliro Clinic  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Christoulas","sequence":"additional","affiliation":[{"name":"Department of Haematology 251 General AirForce Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Dellatola","sequence":"additional","affiliation":[{"name":"Department of Hematology Metropolitan Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Hematology Unit, 1st Internal Medicine Department AHEPA University Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menelaos","family":"Papoutselis","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of Alexandroupolis Democritus University of Thrace Medical School  Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Vlachopoulou","sequence":"additional","affiliation":[{"name":"Hematology Unit, First Department of Internal Medicine, Laikon General Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Syrigou","sequence":"additional","affiliation":[{"name":"Hematology Department BMT Unit G. 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