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Compared to healthy donors, CLL patients exhibited significantly elevated CD49d expression in both CD4+ and CD8+ T cells (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) as detected by flow cytometry, which was also confirmed by the single\u2010cell RNA sequencing (scRNA\u2010seq) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Differentially expressed genes in CD49d+ T (both CD8+ and CD4+ T cells) versus CD49d\u2212 T cells identified in CLL patients were enriched in cellular senescence pathways, while this phenomenon is absent in healthy individuals. Functional validation demonstrated that CD49d+ T cells displayed elevated senescence\u2010associated markers (e.g. interferon\u2010gamma, granzyme B) and a shift towards memory phenotypes, correlating with immunosuppressive signatures. This discovery suggests that targeting CD49d\u2010dependent senescence pathways may reverse T\u2010cell dysfunction in CLL immunotherapy.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20135","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:33:39Z","timestamp":1747355619000},"page":"80-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD49d promotes T\u2010cell senescence in chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"207","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, Jiangsu Province Hospital The First Affiliated Hospital of Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing 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