{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:08:57Z","timestamp":1788365337853,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070160"],"award-info":[{"award-number":["82070160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170182"],"award-info":[{"award-number":["82170182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370165"],"award-info":[{"award-number":["82370165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400134"],"award-info":[{"award-number":["82400134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470153"],"award-info":[{"award-number":["82470153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470163"],"award-info":[{"award-number":["82470163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022JC012"],"award-info":[{"award-number":["2022JC012"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH228"],"award-info":[{"award-number":["ZR2023MH228"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Genetic abnormalities in acute myeloid leukaemia (AML) patients are usually conducted in small or regional studies; there is currently a lack of research on whether genetic abnormalities in each continent have regional specificity. In this study, we collected and jointly analysed studies published between 1995 and 2023 that reported on molecular and cytogenetic abnormalities of AML patients. Our findings reveal that the incidence of molecular genetic abnormalities has been increasing annually, whereas cellular genetic abnormalities show an overall declining trend. We performed cluster analysis and developed a prognostic risk model to uncover that AML patients with molecular genetic abnormalities, or both types of genetic abnormalities, have a relatively lower risk in Europe. In contrast, AML patients in Asia with cytogenetic abnormalities exhibit a comparatively lower risk. We also found that spliceosome co\u2010mutations were dominant among molecular genetic abnormalities, but the synergistic correlation between cytogenetic abnormalities is minimal. Our study offers valuable insights in AML risk levels across different regions, based on prognostic classification and regional risk stratification, and underscores the clinical significance of gene mutations, chromosomal abnormalities, and their co\u2010occurrence, highlighting their role in understanding the disease's pathogenesis and informing treatment strategies.<\/jats:p>","DOI":"10.1111\/bjh.20138","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:15:24Z","timestamp":1746497724000},"page":"395-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Global spatiotemporal distribution characteristics and regional risk stratification model of acute myeloid leukaemia based on molecular genetics and cytogenetic features"],"prefix":"10.1111","volume":"207","author":[{"given":"Jilong","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjing","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-582X","authenticated-orcid":false,"given":"Guangqiang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-8235","authenticated-orcid":false,"given":"Jingjing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"},{"name":"Shandong Key Laboratory of Hematological Diseases and Immune Microenvironment Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"},{"name":"Shandong Key Laboratory of Hematological Diseases and Immune Microenvironment Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4438-1768","authenticated-orcid":false,"given":"Chunyan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"},{"name":"Shandong Key Laboratory of Hematological Diseases and Immune Microenvironment Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22233"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0025"},{"issue":"8","key":"e_1_2_14_7_1","first-page":"2931","article-title":"Karyotype in acute myeloblastic leukemia: prognostic significance for bone marrow transplantation in first remission: a European Group for Blood and Marrow Transplantation study. Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)","volume":"90","author":"Ferrant A","year":"1997","journal-title":"Blood"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971201)80:11 <2176::AID-CNCR2>3.0.CO;2-G"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3424-4"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133190"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqab172"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-462440"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.163"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-254441"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404055"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.107"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2540-7"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.181842"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024185"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281233"},{"issue":"8","key":"e_1_2_14_21_1","first-page":"4695","article-title":"Decreased SFRP2 expression is associated with intermediate and poor karyotypes in de novo acute myeloid leukemia","volume":"7","author":"Guo H","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"e_1_2_14_22_1","first-page":"145","article-title":"Hereditary disorders in the Eastern Mediterranean Region","volume":"72","author":"Hamamy H","year":"1994","journal-title":"Bull World Health Organ"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-anchem-062012-092628"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200216"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-283291"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02500-y"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01228-0"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.126"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.209"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-571018"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-688705"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.20138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:04:32Z","timestamp":1756364672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.20138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/bjh.20138"],"URL":"https:\/\/doi.org\/10.1111\/bjh.20138","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,5]]},"assertion":[{"value":"2025-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}