{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:37:22Z","timestamp":1788028642391,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 109\u20102314\u2010B\u2010002\u2010223"],"award-info":[{"award-number":["MOST 109\u20102314\u2010B\u2010002\u2010223"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 110\u20102314\u2010B\u2010002\u2010075"],"award-info":[{"award-number":["MOST 110\u20102314\u2010B\u2010002\u2010075"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Dedicator of cytokinesis 1<\/jats:italic>\n                    (\n                    <jats:italic>DOCK1<\/jats:italic>\n                    ), a guanine nucleotide exchange factor for the small GTPase Rac, has been implicated in various biological processes, but its pathological roles in acute myeloid leukaemia (AML) remain unexplored. In this study, we analysed the clinical impacts of\n                    <jats:italic>DOCK1<\/jats:italic>\n                    expression in 341 patients with de novo non\u2010M3 AML treated with standard chemotherapy. The results showed that high\n                    <jats:italic>DOCK1<\/jats:italic>\n                    expression is an independent adverse prognostic factor. Consistent with this, experiments using cell lines, xenografts and\n                    <jats:italic>Dock1<\/jats:italic>\n                    conditional\u2010knockout mice all demonstrated the pro\u2010survival effects of\n                    <jats:italic>DOCK1<\/jats:italic>\n                    in AML cells. This observation was corroborated by findings that the absence of Dock1 ameliorated the\n                    <jats:italic>MN1<\/jats:italic>\n                    \u2010induced AML phenotypes. Transcriptome analyses demonstrated an association between\n                    <jats:italic>DOCK1<\/jats:italic>\n                    expression and upregulated Notch signalling, and the causal relationship was supported by cell line experiments. Furthermore, single\u2010cell RNA sequencing of\n                    <jats:italic>MN1<\/jats:italic>\n                    \u2010induced mouse AML cells revealed a unique cluster with upregulated stem cell functions and\n                    <jats:italic>Hes1<\/jats:italic>\n                    , a Notch target, in the\n                    <jats:italic>Dock1<\/jats:italic>\n                    wild type but not knockout background. These findings underscore the clinical and pathogenic significance of\n                    <jats:italic>DOCK1<\/jats:italic>\n                    in AML and support its potential as a therapeutic target.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20140","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T20:59:17Z","timestamp":1747083557000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inhibition of\n                    <i>DOCK1<\/i>\n                    suppresses Notch signalling pathway and impairs leukaemogenesis"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-9686","authenticated-orcid":false,"given":"Ming\u2010En","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine, National Taiwan University  Taipei Taiwan"},{"name":"Division of Hematology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh\u2010Chwen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh\u2010Ling","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Medical Research National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5052-9445","authenticated-orcid":false,"given":"Chi\u2010Yuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chein\u2010Jun","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Tsu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Lang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Medical Research National Taiwan University Hospital  Taipei 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