{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:14:08Z","timestamp":1760746448261,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Luspatercept has emerged as a valuable therapeutic option for patients with transfusion\u2010dependent \u03b2\u2010thalassaemia, enabling significant reduction in transfusion requirements. In the report by Zaidel et\u00a0al., a paradoxical clinical scenario is described in which treatment with luspatercept was associated with progressive splenomegaly, thrombocytopenia, increased haemolysis and a marked rise in reticulocytes and nucleated red blood cells, promptly reversible upon drug discontinuation. Luspatercept usually enhances late\u2010stage erythroid maturation, but, in rare cases like this, seems to trigger or exacerbate extramedullary haematopoiesis (EMH) and\/or splenic sequestration. The report underscores the importance of close monitoring and a deeper understanding of individual susceptibility to optimize the safe use of luspatercept in thalassaemia. Further studies are needed to clarify the underlying mechanisms and to identify patients at risk for EMH\u2010related complications during luspatercept treatment.<\/jats:p><jats:p>Commentary on: Zaidel et al. Acute splenomegaly, haemolysis, and thrombocytopenia following luspatercept initiation in a patient with transfusion\u2010dependent thalassaemia: A case report. Br J Haematol 2025; 206:1806\u20101810.<\/jats:p>","DOI":"10.1111\/bjh.20142","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:08:37Z","timestamp":1747188517000},"page":"1879-1880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The double edge of erythropoietic modulation in thalassaemia"],"prefix":"10.1111","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-3308","authenticated-orcid":false,"given":"Paolo","family":"Ricchi","sequence":"first","affiliation":[{"name":"Unit\u00e0 Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso Azienda Ospedaliera di Rilievo Nazionale \u201cA. Cardarelli\u201d  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.20131"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011045"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3512"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910182"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27474"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000029334"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18470"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18801"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1385-y"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207231195594"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.20142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T08:23:01Z","timestamp":1760689381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.20142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/bjh.20142"],"URL":"https:\/\/doi.org\/10.1111\/bjh.20142","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"2025-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}