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Despite the availability of various immunotherapeutic strategies, patient survival rates remain disappointingly low, thus underscoring the need for innovative immunotherapies to improve outcomes. Leukocyte Ig\u2010like receptor subfamily B (LILRB1), which is a recently identified immune checkpoint, has an undefined role and molecular mechanism in MM. Herein, we demonstrated that LILRB1 was significantly upregulated in MM patients and MM cell lines and was negatively correlated with patient survival. The knockdown of LILRB1 promoted apoptosis in MM cells, enhanced sensitivity to bortezomib and diminished tumourigenicity in a subcutaneous mouse model. Mechanistically, LILRB1 triggers downstream GATA Binding Protein 2 (GATA2) and sustains MM cell proliferation via the GATA2\u2013Sarcoma Antigen 1 (SAGE1) signalling pathway. Consequently, the targeting of LILRB1 may represent a promising therapeutic approach for MM.<\/jats:p>","DOI":"10.1111\/bjh.20144","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T02:24:01Z","timestamp":1748226241000},"page":"69-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The progression of multiple myeloma is regulated by\n                    <scp>LILRB1<\/scp>\n                    via the\n                    <scp>GATA2<\/scp>\n                    \u2013\n                    <scp>SAGE1<\/scp>\n                    pathway"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-8212","authenticated-orcid":false,"given":"Chiqi","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Hongqiao International Institute of 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