{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:24:16Z","timestamp":1782512656597,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19KK0248"],"award-info":[{"award-number":["19KK0248"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Acute physical exercise may trigger vaso\u2010occlusive crises (VOC) in patients with sickle cell anaemia (SCA), creating uncertainty around physical activity (PA) recommendations. This cross\u2010sectional study examined the relationships between PA, VOC and steady\u2010state pain in 104 Senegalese male patients with SCA. PA was objectively measured over 5\u2009weeks, recording daily steps and time spent in different PA intensities (expressed in metabolic equivalent of task, MET). VOC occurrence was tracked, and steady\u2010state days excluded VOC days plus 2\u2009days before and after. Pain frequency and intensity on steady\u2010state days were recorded via diaries, and blood viscosity was measured. Ninety\u2010eight patients (29\u2009\u00b1\u20098\u2009years old) completed the study, averaging 9611\u2009\u00b1\u20094040 steps\/day, with 293\u2009\u00b1\u2009108, 64\u2009\u00b1\u200969 and 28\u2009\u00b1\u200932\u2009min in \u22651.5, \u22653.0, and \u22656.0 MET PA respectively. Median daily step count and PA duration were not associated with VOC occurrence. However, higher step counts and more time in \u22651.5 and \u22656.0 MET PA correlated with lower pain frequency and intensity (on steady\u2010state days) and lower blood viscosity. These findings suggest that PA may benefit patients with SCA, but further research is needed to establish guidelines.<\/jats:p>","DOI":"10.1111\/bjh.20150","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T05:34:38Z","timestamp":1747719278000},"page":"206-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Physical activity, vaso\u2010occlusive crises and pain in patients with sickle cell anaemia in Senegal"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-6235","authenticated-orcid":false,"given":"Mor","family":"Diaw","sequence":"first","affiliation":[{"name":"Laboratoire de Physiologie Humaine, Facult\u00e9 de M\u00e9decine, de Pharmacie et d'Odontologie Universit\u00e9 Cheikh Anta Diop  Dakar Senegal"},{"name":"IRL3189\u2014CNRS Environnement, Sant\u00e9, Soci\u00e9t\u00e9s  Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-9365","authenticated-orcid":false,"given":"Mame Saloum","family":"Coly","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiologie et Explorations Fonctionnelles, UFR des Sciences de la Sant\u00e9 Universit\u00e9 Iba Der Thiam de Thi\u00e8s  Thi\u00e8s Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4366-4013","authenticated-orcid":false,"given":"Keyne","family":"Charlot","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Unit\u00e9 de Physiologie des Exercices et Activit\u00e9s en Conditions Extr\u00eames D\u00e9partement Environnements Op\u00e9rationnels  Bretigny\u2010Sur\u2010Orge France"},{"name":"LBEPS, Univ Evry, IRBA, Universit\u00e9 Paris Saclay  Evry 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