{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:08:00Z","timestamp":1771466880626,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012051","name":"Lupus Research Alliance","doi-asserted-by":"publisher","award":["519414"],"award-info":[{"award-number":["519414"]}],"id":[{"id":"10.13039\/100012051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL158606"],"award-info":[{"award-number":["R01 HL158606"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Natural autoantibodies (NAAbs) are immunoglobulins generated in the absence of antigen provocation, with no inherent pathogenic effect, but instead involved in maintaining immune homeostasis. We aimed to evaluate the implication of immunoglobulin G (IgG) antibodies against heat shock protein 90\u03b1 (HSP90\u03b1) in systemic lupus erythematosus (SLE) patients, focusing on how those NAAbs may interfere with the immunothrombosis process. Anti\u2010HSP90\u03b1 IgG was measured by an enzyme\u2010linked immunosorbent assay in the plasma of 308 SLE individuals, paired with 308 healthy controls (HC). Validation was performed in another cohort, comprised of serum from 125 SLE and 77 HC. In an in\u00a0vitro experiment, platelets were cultured with mitochondria (abundant sources of HSP90\u03b1) treated with anti\u2010HSP90\u03b1 IgG, and the activation markers thrombospondin\u20101 and platelet factor 4 were measured in the supernatant. Levels of anti\u2010HSP90\u03b1 IgG were comparable in SLE and HC, but decreased in the SLE patients with secondary antiphospholipid syndrome (APS), both in the exploratory and the validation cohort (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0265, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0472 respectively). Mitochondria triggered platelet activation in a TLR2\u2010 and HSP90\u03b1\u2010dependent manner (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0152 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 respectively). Anti\u2010HSP90\u03b1 IgG emerges as a prominent NAAb\u2010modulating immunothrombosis in SLE and holds promise as a biomarker of APS risk in these patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20156","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T06:20:47Z","timestamp":1747635647000},"page":"201-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010\n                    <scp>HSP90\u03b1 IgG<\/scp>\n                    may protect against antiphospholipid syndrome in systemic lupus erythematosus by reducing platelet activation"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8927-5566","authenticated-orcid":false,"given":"Marina","family":"Barguil Mac\u00eado","sequence":"first","affiliation":[{"name":"Division of Rheumatology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"J\u00f6nsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Rheumatology Lund University, Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders A.","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Rheumatology Lund University, Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Solna Karolinska Institutet, Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Svenungsson","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine Solna Karolinska Institutet, Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lood","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010020\u20100480\u20107"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.1.2.213"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0895"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/14.5.453"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445293"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.5"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39656"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42428"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2006.01753.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42624"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000640\u20109"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2022.8443"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/796869"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348\u20100421.2010.00214.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201022788\u20108"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/728605"},{"issue":"6","key":"e_1_2_12_18_1","first-page":"928","article-title":"Revisiting anti\u2010hsp90 antibodies in systemic lupus erythematosus","volume":"28","author":"Dal Ben ER","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102249.2002.01887.x"}],"container-title":["British Journal of 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