{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:04:28Z","timestamp":1784379868603,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The UK National Cancer Research Institute (NCRI) phase 2 randomised CHOP versus GEM\u2010P in previously untreated patients with peripheral T\u2010cell lymphoma (CHEMO\u2010T) trial compared the regimens of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) and gemcitabine, cisplatin and methylprednisolone (GEM\u2010P) in treatment\u2010na\u00efve patients with peripheral T\u2010cell lymphoma (PTCL). Evaluation of the role of positron emission tomography\/computed tomography (PET\/CT) was a key secondary end\u2010point. All patients required PET\/CT, contrast\u2010enhanced CT (CECT) and bone marrow biopsy (BMB) at enrolment and end of treatment (EOT). Baseline (BL) data for PET\/CT (<jats:sub>BL<\/jats:sub>PET\/CT), CECT and BMB were compared. Response by CECT and PET\/CT was correlated with outcomes. <jats:sub>BL<\/jats:sub>PET\/CT data were available for 82\/84; 98% (80\/82) had FDG\u2010avid disease. <jats:sub>BL<\/jats:sub>PET\/CT altered disease stage in 43% and identified additional extranodal sites (most frequently bone marrow\/bone <jats:italic>n<\/jats:italic>\u2009=\u20097) in 25% versus CECT. Concordance of <jats:sub>BL<\/jats:sub>PET\/CT with BMB for marrow involvement was 72.6%, with discordant results for <jats:italic>n<\/jats:italic>\u2009=\u200920. Ten patients with biopsy\u2010proven marrow infiltration had a PET\/CT\u2010negative marrow. However, <jats:sub>BL<\/jats:sub>PET\/CT detected marrow involvement in patients with a negative BMB (<jats:italic>n<\/jats:italic>\u2009=\u200910), predominantly cases with focal uptake (7\/10). At EOT, a negative PET\/CT (vs. positive) was associated with superior 2\u2010year progression\u2010free survival (PFS) of 55% (95% CI: 38%\u201370%) versus 29% (95% CI: 12%\u201348%) [HR 0.45 (95% CI: 0.23\u20130.88), <jats:italic>p<\/jats:italic>\u2009=\u20090.021], respectively, which remained independently prognostic. Our findings indicate that PET\/CT should be incorporated as a standard of care in the management of PTCL.<\/jats:p>","DOI":"10.1111\/bjh.20160","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T21:39:48Z","timestamp":1748295588000},"page":"407-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of <scp>PET<\/scp>\/<scp>CT<\/scp> in peripheral T\u2010cell lymphoma: Results from the <scp>PET<\/scp>\/<scp>CT<\/scp> substudy of the <scp>UK NCRI<\/scp> phase 2 <scp>CHEMO<\/scp>\u2010T trial"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-9878","authenticated-orcid":false,"given":"M.","family":"Gleeson","sequence":"first","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gonzalez Arias","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust  London and Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5158-1069","authenticated-orcid":false,"given":"D.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust  London and Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Peckitt","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust  London and Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Thomas","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust  London and Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Du","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust  London and Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hujairi","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust  London and Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. M.","family":"To","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust  London and Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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