{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:55:10Z","timestamp":1784876110961,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013189"],"award-info":[{"award-number":["2024A1515013189"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770156"],"award-info":[{"award-number":["81770156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7192213"],"award-info":[{"award-number":["7192213"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Recent studies revealed that\n                    <jats:italic>CEBPA<\/jats:italic>\n                    with basic leucine zipper (bZIP) in\u2010frame mutation (\n                    <jats:italic>CEBPA<\/jats:italic>\n                    <jats:sup>bZIP\u2010inf<\/jats:sup>\n                    ) is the bona fide entity with a favourable prognosis in acute myeloid leukaemia. However, the mechanism by which the bZIP signatures influence risk stratification remains unclear. We identified 141 patients with\n                    <jats:italic>CEBPA<\/jats:italic>\n                    <jats:sup>bZIP\u2010inf<\/jats:sup>\n                    . Variant allele fraction (VAF) (cumulative incidence of relapse [CIR], VAF\n                    <jats:sup>high<\/jats:sup>\n                    vs. VAF\n                    <jats:sup>low<\/jats:sup>\n                    , 74.0% vs. 27.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and base change (\u2264 vs. &gt;3 bases, 39.1% vs. 60.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042) of bZIP mutations were associated with CIR. These two factors, along with the white blood cell count and measurable residual disease after first consolidation, could stratify patients into three risk subgroups (CIR, low vs. medium vs. high risk, 15.2% vs. 47.1% vs. 83.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Compared with no transplantation, receiving a transplantation significantly decreased the relapse rates in medium\u2010risk (transplantation vs. no transplantation, 11.6% vs. 49.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009) and high\u2010risk patients (5.6% vs. 84.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) but not low\u2010risk (0% vs. 15.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.220). However, only high\u2010risk patients could benefit from transplantation in terms of overall survival (100% vs. 59.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). Our study revealed the heterogeneity of\n                    <jats:italic>CEBPA<\/jats:italic>\n                    <jats:sup>bZIP\u2010inf<\/jats:sup>\n                    patients and suggested a risk\u2010adapted treatment modality. Transplantation is recommended for high\u2010risk patients and consolidation chemotherapy is recommended for low\u2010risk and medium\u2010risk patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20164","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T21:38:46Z","timestamp":1748295526000},"page":"170-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic value of\n                    <scp>\n                      <i>CEBPA<\/i>\n                      bZIP\n                    <\/scp>\n                    signatures in cytogenetically normal acute myeloid leukaemia"],"prefix":"10.1111","volume":"208","author":[{"given":"Li\u2010Xin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Hematology Peking University Shenzhen Hospital, Shenzhen Peking University\u2014The Hong Kong University of Science and Technology Medical Center  Shenzhen Guangdong China"},{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yue","family":"Liao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4143-3961","authenticated-orcid":false,"given":"Nan","family":"Yan","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease Peking University People's Hospital, Peking University Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking University Shenzhen Hospital, Shenzhen Peking University\u2014The Hong Kong University of Science and Technology Medical Center  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Acornmed Biotechnology Co. Ltd.  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4721-0016","authenticated-orcid":false,"given":"Jia\u2010Yue","family":"Qin","sequence":"additional","affiliation":[{"name":"Acornmed Biotechnology Co. Ltd.  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010Bo","family":"Cao","sequence":"additional","affiliation":[{"name":"Acornmed Biotechnology Co. Ltd.  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