{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:14:27Z","timestamp":1791378867280,"version":"4.3.2"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Despite advancements in thalassaemia care, survival rates and complications vary significantly by genotype. This study assesses survival outcomes and associated complications in patients with thalassaemia in north\u2010eastern Thailand. A longitudinal cohort study from October 2012 to September 2023 involved patients aged \u226510\u2009years (median: 31\u2009years, range: 20\u201374) attending Srinagarind and Udonthani Hospitals. Cox regression analyses identified predictors of survival and complications. Of 380 enrolled patients, 340 completed follow\u2010up. Over 10\u2009years, 39 patients (11.4%) died, primarily from cardiovascular complications (61.5%), at a median age of 45\u2009years (range: 22\u201372). Patients were grouped as HbE\/\u03b2\u2010thalassaemia, HbH\/HbHCS with HbE mutation and HbH\/HbHCS. Survival at 60\u2009years was lower in HbE\/\u03b2\u2010thalassaemia (55.9%) and HbH\/HbHCS with HbE mutation (58.3%) compared to HbH\/HbHCS (79.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.08). Significant predictors of mortality included cardiovascular complications (HR 2.4; 95% CI, 1.01\u20135.5;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04), recurrent bacterial infections (HR 7.6; 95% CI, 3.1\u201318.8;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and elevated ferritin (&gt;2500\u2009ng\/mL; HR 2.0; 95% CI, 1.01\u20133.9;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). Cardiovascular complications, recurrent bacterial infections and high ferritin levels significantly influence survival in thalassaemia patients. Deletional alpha\u2010thalassaemia patients had superior survival, while HbE\/\u03b2\u2010thalassaemia and non\u2010deletional alpha\u2010thalassaemia or co\u2010inherited HbE mutation had poorer outcomes, underscoring the need for genotype\u2010specific management strategies.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20179","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T01:33:47Z","timestamp":1748309627000},"page":"552-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Survival and thalassaemia\u2010related complications in\n                    <scp>HbE<\/scp>\n                    \/beta\u2010thalassaemia and alpha\u2010thalassaemia: A 10\u2010year longitudinal study in Thailand"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2364-1498","authenticated-orcid":false,"given":"Nattiya","family":"Teawtrakul","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Srinagarind Hospital, Faculty of Medicine, Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunee","family":"Jetsrisuparb","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Pediatrics Srinagarind Hospital, Faculty of Medicine, Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Pongudom","sequence":"additional","affiliation":[{"name":"Hematology Unit Udonthani Hospital  Udonthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchana","family":"Chansung","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Srinagarind Hospital, Faculty of Medicine, Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittima","family":"Sirijerachai","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Srinagarind Hospital, Faculty of Medicine, Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supan","family":"Fucharoen","sequence":"additional","affiliation":[{"name":"Center for Research and Development of Medical Diagnostic Laboratories Faculty of Associated Medical Science, Khon Kaen University  Khon Kaen 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