{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:30:51Z","timestamp":1788049851510,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300240"],"award-info":[{"award-number":["82300240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470210"],"award-info":[{"award-number":["82470210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) has been reported to further sustain long\u2010term leukaemia\u2010free survival following chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy. It remains unclear whether bridging CAR\u2010T to allo\u2010HSCT results in higher treatment\u2010related toxicity and mortality. We conducted a retrospective study to compare outcomes between allo\u2010HSCT after CAR\u2010T or conventional chemotherapy. After propensity score matching, 62 patients with prior CAR\u2010T therapy and 124 patients with chemotherapy were ultimately included. Patients in the CAR\u2010T cohort had a longer duration time from diagnosis to transplant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and more advanced disease status before HSCT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) than that of the chemotherapy cohort. Patients with prior CAR\u2010T cell therapy had a lower 28\u2010day platelet engraftment rates [Hazard Rate (HR) =\u20091.38, 95% Confidence Interval (CI), 1.02\u20131.87,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037]. Multivariate analysis revealed that CAR\u2010T therapy increased the risk of moderate to severe chronic graft\u2010versus\u2010host disease (cGVHD) (HR\u2009=\u20092.5, 95% CI, 1.01\u20136.19,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.048). Compared with patients in the chemotherapy cohort, those in the CAR\u2010T cell cohort experienced a higher incidence of transplantation\u2010associated thrombotic microangiopathy (6.5% vs. 0.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) and probable\/possible invasive fungal disease (10.0% vs. 3.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.08). The relapse rate, non\u2010relapse mortality, and survival were comparable between cohorts. Caution should be exercised in allo\u2010HSCT following CAR\u2010T therapy because of the higher risk of platelet engraftment failure and cGVHD compared to chemotherapy.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20180","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:23:55Z","timestamp":1749727435000},"page":"162-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Higher risk of platelet engraftment failure and chronic graft\u2010versus\u2010host disease after allogeneic haematopoietic stem cell transplantation following chimeric antigen receptor T\u2010cell therapy compared to chemotherapy: A propensity score\u2010matched analysis"],"prefix":"10.1111","volume":"207","author":[{"given":"Luxin","family":"Yang","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Lai","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Shi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Wu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarui","family":"Fu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxian","family":"Hu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou 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