{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:21:28Z","timestamp":1765534888769,"version":"3.48.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K15323"],"award-info":[{"award-number":["23K15323"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Historically, the presence of measurable disease has been considered essential to stimulate CAR T\u2010cell expansion and persistence. However, the kinetics of CAR T cells in patients achieving complete response (CR) before infusion remain poorly understood. This study aimed to evaluate the outcomes and CAR T\u2010cell kinetics in relapsed\/refractory diffuse large B\u2010cell lymphoma (DLBCL) patients stratified by pre\u2010infusion disease status. In this retrospective analysis of 87 patients treated at a single institution, 23 (26.4%) were in CR and 64 (73.6%) were in non\u2010CR prior to CAR T\u2010cell infusion. Patients in CR exhibited significantly better progression\u2010free survival (PFS) and overall survival compared to non\u2010CR patients. Peripheral blood CAR T\u2010cell kinetics, including the proportion and absolute counts of CAR T cells, CD4+ CAR T cells and CD8+ CART cells, showed no significant differences between CR and non\u2010CR groups. These findings were consistent across different CAR T\u2010cell products, whether 4\u20101BB\u2010 or CD28\u2010based. Moreover, an analysis of patients achieving complete metabolic response (CMR) by PET\u2010CT confirmed comparable CAR T\u2010cell expansion and persistence in both CMR and non\u2010CMR patients. Our findings demonstrate that CAR T\u2010cell therapy achieves robust expansion and favourable survival outcomes in CR patients, even in the absence of measurable disease.<\/jats:p>","DOI":"10.1111\/bjh.20186","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T23:18:27Z","timestamp":1748215107000},"page":"180-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Robust\n                    <scp>CAR<\/scp>\n                    T\u2010cell expansion and superior outcomes in\n                    <scp>DLBCL<\/scp>\n                    patients in complete response at infusion"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-7909","authenticated-orcid":false,"given":"Ryo","family":"Hanajiri","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Nagoya University Graduate School of Medicine  Nagoya 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