{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:06:02Z","timestamp":1785513962922,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>DNA methyltransferase inhibitors (DNMTis) are commonly used in treating chronic myelomonocytic leukaemia (CMML); however, data from prospective studies of DNMTis in CMML are limited. The present analysis evaluated the efficacy, safety and pharmacodynamics of the oral DNMTi decitabine\/cedazuridine in the subset of patients with CMML from the phase 2 and 3 trials, which led to the approval of this agent for myelodysplastic syndromes and CMML in the United States and Canada. Potential prognostic factors also were analysed. In all, 34 patients with CMML were screened and 33 were treated. Most patients (76% [<jats:italic>n<\/jats:italic>\u2009=\u200925]) had myelodysplastic type\u2010CMML and 77% (<jats:italic>n<\/jats:italic>\u2009=\u200924\/31 with DNA available for sequencing) had intermediate\u20102 or high\u2010risk disease noted by CMML\u2010specific prognostic scoring systems. The overall response rate was 76%, with 21% (<jats:italic>n<\/jats:italic>\u2009=\u20097) of patients achieving a complete response. Nearly half of the 11 patients who were red blood cell\u2010transfusion dependent at baseline (46%) attained transfusion independence for \u226512\u2009weeks, which was associated with survival. Median overall and transformation\u2010free survival were 35.7 and 28.3\u2009months, respectively, and the safety profile was similar to that previously reported for decitabine. This analysis described the use of decitabine\/cedazuridine in CMML from consecutive, prospective, randomised trials and illustrated a median survival of nearly 3\u2009years.<\/jats:p>","DOI":"10.1111\/bjh.20203","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:14:54Z","timestamp":1750119294000},"page":"432-444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of oral decitabine\/cedazuridine in the chronic myelomonocytic leukaemia subpopulations from phase 2 and 3 studies"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-5504","authenticated-orcid":false,"given":"Michael R.","family":"Savona","sequence":"first","affiliation":[{"name":"Vanderbilt\u2010Ingram Cancer Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olatoyosi","family":"Odenike","sequence":"additional","affiliation":[{"name":"University of Chicago and the University of Chicago Comprehensive Cancer Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail J.","family":"Roboz","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine and New York\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshad","family":"Amin","sequence":"additional","affiliation":[{"name":"BRCR Global  Plantation Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"DeZern","sequence":"additional","affiliation":[{"name":"The Sidney Kimmel Comprehensive Cancer Center The Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim\u2010Hien","family":"Dao","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-8160","authenticated-orcid":false,"given":"Amer M.","family":"Zeidan","sequence":"additional","affiliation":[{"name":"Yale University and Yale Cancer Center  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavana","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"WVU Cancer Institute at Wheeling Hospital  Wheeling West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-7386","authenticated-orcid":false,"given":"Rena","family":"Buckstein","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Leber","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u2010Margaret","family":"Keating","sequence":"additional","affiliation":[{"name":"Queen Elizabeth II Health Sciences Centre  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somedeb","family":"Ball","sequence":"additional","affiliation":[{"name":"Vanderbilt\u2010Ingram Cancer Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Oganesian","sequence":"additional","affiliation":[{"name":"Taiho Oncology, Inc.  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