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The molecular marker of systemic mastocytosis (SM) (<jats:italic>KIT<\/jats:italic>D816V) simultaneously disappeared (median\u2009+\u200936\u2009days) with the establishment of donor chimerism (median: +31\u2009days post\u2010HCT; Pearson correlation: \u22120.99, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In contrast, tryptase normalized median of +228\u2009days after HCT with significant delay to <jats:italic>KIT<\/jats:italic>D816V clearance (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) and full donor chimerism (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Faster normalization was observed after radiation\u2010based conditioning and removal of an infiltrated spleen, while persistence was not associated with relapse of AHN.<\/jats:p>","DOI":"10.1111\/bjh.20211","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:53:26Z","timestamp":1750211606000},"page":"509-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Different clearance of <i>KIT<\/i>D816V mutation and tryptase levels after haematopoietic cell transplantation in patients with systemic mastocytosis with associated haematological neoplasm"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-1011","authenticated-orcid":false,"given":"Christian","family":"Niederwieser","sequence":"first","affiliation":[{"name":"Department of Stem Cell Transplantation University Medical Center Hamburg\u2010Eppendorf  Hamburg 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