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One hundred and nine patients aged between 6.7 and 72.3\u2009years (median: 32\u2009years), including 97 with \u03b1\u2010thalassaemia intermedia and 12 with \u03b2\u2010thalassaemia intermedia, were included from two public hospitals. Among them, 82% had never been transfused and 18% had received sporadic transfusions. Chelation therapy had been given to 7% of patients. Notably, 52% of patients had chronic health deficits with a strong positive correlation with advanced age, log\u2010transformed ferritin levels and history of splenectomy. Hepatic iron overload was detected in 43% of patients, and extramedullary haematopoiesis in 14%. At least one endocrinopathy developed in 12% of patients. Patients with non\u2010deletional \u03b1\u2010thalassaemia intermedia and \u03b2\u2010thalassaemia intermedia exhibited more severe disease than those with deletional \u03b1\u2010thalassaemia intermedia. This study highlighted the need for ongoing monitoring and management strategies for NTDT to mitigate chronic health issues and improve outcomes.<\/jats:p>","DOI":"10.1111\/bjh.20212","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T04:13:46Z","timestamp":1750824826000},"page":"1058-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron overload and morbidities in Chinese with non\u2010transfusion\u2010dependent thalassaemia"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-064X","authenticated-orcid":false,"given":"Wing\u2010yan","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Kowloon Bay Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy Yuen\u2010han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Tuen Mun Hospital  Tuen Mun Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010yan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Mary Hospital  Pok Fu Lam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine Tsz\u2010man","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital The University of Hong Kong  Pok Fu Lam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-0561","authenticated-orcid":false,"given":"Chun\u2010Fung","family":"Sin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital The University of Hong Kong  Pok Fu Lam Hong 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