{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:23:52Z","timestamp":1792106632074,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Chimeric antigen receptor (CAR) T\u2010cell therapy has reshaped the treatment paradigm for relapsed\/refractory (R\/R) diffuse large B\u2010cell lymphoma (DLBCL). However, its role in central nervous system lymphoma (CNSL) remains uncertain. We conducted a multicentre, retrospective study on 54 adult R\/R CNSL patients treated at four international institutions with commercial (axi\u2010cel, tisa\u2010cel, liso\u2010cel) or a point of care (POC) CD19\u2010CAR T\u2010cell products. At day 100 post CAR\u2010T infusion, 65% of patients attained a complete response as their best response in both systemic and central nervous system compartments. The median progression\u2010free survival (PFS) was 7.5\u2009months, with a 1\u2010year PFS of 35%. The median overall survival (OS) was 19\u2009months, with a 1\u2010year OS of 63%. In multivariable analyses, CAR\u2010T product was significantly associated with PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009) and OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013), with patients receiving tisa\u2010cel exhibiting poorer outcomes than axi\u2010cel and patients receiving liso\u2010cel or POC CAR\u2010T product demonstrating better outcomes than axi\u2010cel. Toxicity profiles were consistent with pivotal trials in R\/R DLBCL. Grade \u22653 cytokine release syndrome occurred in 11% of patients, while grade \u22653 immune\u2010effector cell\u2010associated neurotoxicity syndrome was observed in 28%. Our study supports the feasibility and safety of anti\u2010CD19 CAR\u2010T therapy in CNSL. The specific CAR\u2010T product infused emerged as a factor influencing outcomes.\n                  <\/jats:p>","DOI":"10.1111\/bjh.20234","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T03:10:21Z","timestamp":1751339421000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of\n                    <scp>CD19 CAR<\/scp>\n                    \u2010T therapy in central nervous system lymphoma: Insights from a multicentre experience"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2192-9930","authenticated-orcid":false,"given":"Giulio","family":"Cassanello","sequence":"first","affiliation":[{"name":"Department of Medicine, Adult Bone Marrow Transplantation Service Memorial Sloan Kettering Cancer Centre  New York New York USA"},{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-2135","authenticated-orcid":false,"given":"Efrat","family":"Luttwak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lymphoma Service Memorial Sloan Kettering Cancer Centre  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Centre  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Devlin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Centre  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Imber","sequence":"additional","affiliation":[{"name":"Department of Radio\u2010Oncology Memorial Sloan Kettering Cancer Centre  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-5618","authenticated-orcid":false,"given":"Andrew","family":"Ip","sequence":"additional","affiliation":[{"name":"Hackensack University Medical Centre  Hackensack New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Leslie","sequence":"additional","affiliation":[{"name":"Hackensack University Medical Centre  Hackensack New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa Golan","family":"Accav","sequence":"additional","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation Chaim Sheba Medical Centre  Tel HaShomer Israel"},{"name":"School of Medicine, Faculty of Medical and Health Sciences Aviv University  Tel\u2010Aviv 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Centre  New York New York USA"},{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Rivas Delgado","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lymphoma Service Memorial Sloan Kettering Cancer Centre  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Lue","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lymphoma Service Memorial Sloan Kettering Cancer Centre  New York New York USA"},{"name":"Department of Medicine Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Grommes","sequence":"additional","affiliation":[{"name":"Department of Neuro Oncology Memorial Sloan Kettering Cancer Centre  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan 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