{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:49:48Z","timestamp":1782730188673,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA247815"],"award-info":[{"award-number":["T32CA247815"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Baseline risk factors for acute kidney injury (AKI) during chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy are not well described. Hence, we evaluated the incidence and risk factors associated with AKI among patients undergoing CAR\u2010T for relapsed\/refractory large B\u2010cell lymphoma. Among 155 patients, 28 (18%) developed AKI with a median time\u2010to\u2010peak creatinine from CAR\u2010T of 9.5\u2009days (range\u2009=\u20093\u201330). Aetiologies included volume depletion (<jats:italic>n<\/jats:italic>\u2009=\u200920, 71%), cytokine release syndrome (<jats:italic>n<\/jats:italic>\u2009=\u20095, 18%), nephrotoxins (<jats:italic>n<\/jats:italic>\u2009=\u20095, 18%), tumour lysis syndrome (<jats:italic>n<\/jats:italic>\u2009=\u20091, 4%) and multifactorial (<jats:italic>n<\/jats:italic>\u2009=\u20096, 21%). On univariable analysis, a history of chronic kidney disease (CKD) relative risk (RR 3.5, 95% CI: 1.9\u20136.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), receipt of axicabtagene ciloleucel (RR 2.1, 95% CI: 1.1\u20134.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), elevated ferritin (RR 3.1, 95% CI: 1.1\u20138.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) and serum creatinine level (RR 2.9, 95% CI: 1.4\u20136.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were associated with AKI. On multivariable analysis, a history of CKD adjusted relative risk (aRR 3.5, 95% CI: 1.9\u20136.4, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and receipt of axicabtagene ciloleucel (aRR 2.1, 95% CI: 1.1\u20134.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) retained statistical significance. Four (2.6%) patients required renal replacement therapy during CAR\u2010T. Twenty\u2010five of 28 patients with AKI had renal recovery with a median time to recovery of 14\u2009days (range\u2009=\u20095\u201385). Of those without renal recovery, two required long\u2010term haemodialysis and one experienced disease progression and died 34\u2009days after CAR\u2010T. Patients with AKI had shorter median PFS (2.4 vs. 6.9\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and OS (7.8 vs. 29.7\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Additional research is needed to obviate the risk of renal toxicity and improve post\u2010CAR\u2010T outcomes.<\/jats:p>","DOI":"10.1111\/bjh.20240","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T12:22:17Z","timestamp":1752409337000},"page":"992-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute kidney injury after chimeric antigen receptor T\u2010cell therapy is associated with inferior survival in patients with\u00a0relapsed\/refractory large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-8549","authenticated-orcid":false,"given":"John","family":"Sharp","sequence":"first","affiliation":[{"name":"Division of Hematology The Ohio State University James Comprehensive Cancer Center and Solove Research Institute  Columbus Ohio 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