{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:11:05Z","timestamp":1781629865016,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Data on late morbidity and survival in nodal peripheral T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>) are scarce. This study investigated the incidence, subtype distribution, late morbidity and survival outcomes of nodal <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> in Finland. The study compared 998 patients with nodal PTCL diagnosed between 2007 and 2019 with matched controls. Data from four nationwide Finnish healthcare registries were used. PTCL not otherwise specified was the most common subtype, with a mean annual incidence of 0.62 (0.45\u20130.87) per 100\u2009000. The 1\u2010year survival was 34% for patients aged &lt;70\u2009years and 49% for those aged \u226570\u2009years. In the younger group, an increased risk of chronic heart failure (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>], 4.17 [2.16\u20138.05]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was observed after <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> diagnosis. The risks of pneumonia (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 6.47 [4.40\u20139.53]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 2.78 [2.010\u20133.859]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and thrombosis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 16.09 [4.22\u201361.39]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 5.34 [2.33 to <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly higher in the younger and older age groups than that in controls. The prognosis of nodal <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> is poor, and patients have a significantly higher risk of comorbidities than controls, irrespective of age. Therefore, targeted and less toxic treatment modalities are required.<\/jats:p>","DOI":"10.1111\/bjh.20253","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T04:33:33Z","timestamp":1752208413000},"page":"851-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nodal peripheral T\u2010cell lymphoma in Finland between 2007 and 2019: Incidence, late morbidity and survival"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-2582","authenticated-orcid":false,"given":"Anu","family":"Partanen","sequence":"first","affiliation":[{"name":"Department of Medicine Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino","family":"R\u00f6nk\u00e4","sequence":"additional","affiliation":[{"name":"Department of Oncology Kuopio University Hospital  Kuopio Finland"},{"name":"Institute of Clinical Medicine, University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Anttalainen","sequence":"additional","affiliation":[{"name":"Medaffcon Oy  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Ukkola\u2010Vuoti","sequence":"additional","affiliation":[{"name":"Medaffcon Oy  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iiro","family":"Toppila","sequence":"additional","affiliation":[{"name":"Medaffcon Oy  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Kuitunen","sequence":"additional","affiliation":[{"name":"Cancer Centre Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatu","family":"Miettinen","sequence":"additional","affiliation":[{"name":"Takeda Oy  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Kuittinen","sequence":"additional","affiliation":[{"name":"Department of Oncology Kuopio University Hospital  Kuopio Finland"},{"name":"Institute of Clinical Medicine, University of Eastern Finland  Kuopio 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