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Due to the scarcity of large multicentre epidemiological studies on paediatric HLH in China, we performed a national analysis to characterize disease burden and features, providing evidence for high\u2010risk identification and resource allocation. We analysed national epidemiological data on paediatric HLH hospitalizations in China using the FUTURE database (2016\u20132022; 33 children's hospitals). HLH accounted for 0.7803\u2030 of paediatric hospitalizations, predominantly affecting children aged 1\u20133\u2009years (34.33%). From 2016 to 2022, the proportion of paediatric HLH hospitalizations showed a declining trend, with the most notable decrease observed during 2020\u20132022. Respiratory diseases (41.07%) were the most common concomitant condition. Infants aged 29\u2009days to &lt;1\u2009year (odds ratio [OR]\u2009=\u20093.11, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and patients from Northwest (OR\u2009=\u20092.68, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and Southwest regions (OR\u2009=\u20091.87, <jats:italic>p<\/jats:italic>\u2009=\u20090.043) had higher mortality risks. Infection\u2010associated HLH (86.09%) was the most common subtype, with Epstein\u2013Barr virus (EBV) as the leading trigger. Central nervous system (CNS)\u2010HLH showed higher risks of multi\u2010organ damage. In Chinese paediatric HLH inpatients, the number of concomitant conditions positively correlated with hospital stay and costs. Different HLH subtypes exhibited distinct clinical features, highlighting the importance of tailored management approaches based on disease classification and risk stratification.<\/jats:p>","DOI":"10.1111\/bjh.20256","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:39:01Z","timestamp":1752626341000},"page":"881-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hospitalization trends and clinical burden of paediatric haemophagocytic lymphohistiocytosis in a multicentre study in China"],"prefix":"10.1111","volume":"207","author":[{"given":"Dilara","family":"Dilmurat","sequence":"first","affiliation":[{"name":"Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital Capital Medical University, National Center for Children's Health  Beijing China"},{"name":"Research Unit of Critical Infection in Children, 2019RU016 Chinese 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