{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:50:44Z","timestamp":1790272244214,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We retrospectively evaluated the treatment outcomes of 47 adult patients with TP53\u2010mutated acute lymphoblastic leukaemia (ALL) treated with either blinatumomab, inotuzumab or\/and CD19 CAR T\u2010cell therapy. The complete remission with or without count recovery (CR\/CRi) (negative minimal residual disease (MRD\u2212) rate) following treatment with blinatumomab (<jats:italic>n<\/jats:italic>\u2009=\u200946), inotuzumab (<jats:italic>n<\/jats:italic>\u2009=\u200926) and CD19 CAR T cells (<jats:italic>n<\/jats:italic>\u2009=\u20096) was 58.7% (96.3%), 61.5% (60%) and 66.7% (75%) respectively. The median OS was 13.6\u2009months (95% CI: 9.6\u201317.2) for all patients, and it was not significantly different based on the individual novel salvage therapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.40). The 12\u2010month leukaemia\u2010free survival (LFS) for responders to blinatumomab, InO and CAR T cells was 20%, 11% and 0% (<jats:italic>p<\/jats:italic>\u2009=\u20090.743) respectively. Patients who had undergone allogeneic haematopoietic stem cell transplantation (HSCT) post\u2010response had improved 12\u2010month LFS compared to those who did not (35% vs. 9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). Among relapsed patients following blinatumomab, 11 (61%) presented with CD19\u2010negative disease. Hence, targeted and immune\u2010based therapies are effective in inducing high MRD\u2010negative remission rates in adults with B\u2010cell ALL harbouring <jats:italic>TP53<\/jats:italic> mutations. Nonetheless, the durability of remission is short in the absence of allogeneic HCT consolidation and relapse frequently manifested as CD19\u2010negative disease following blinatumomab.<\/jats:p>","DOI":"10.1111\/bjh.20260","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T03:03:04Z","timestamp":1756782184000},"page":"1377-1387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The efficacy of targeted and immune\u2010based therapies in adults with <scp>TP53<\/scp>\u2010mutated acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-4612","authenticated-orcid":false,"given":"Hoda","family":"Pourhassan","sequence":"first","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center  Duarte California 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