{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:37:03Z","timestamp":1784889423163,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y\u2010SYBLD2022RWR\u20100017"],"award-info":[{"award-number":["Y\u2010SYBLD2022RWR\u20100017"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2510500"],"award-info":[{"award-number":["2024YFC2510500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"Summary<\/jats:title>Letermovir (LTV) effectively prevents cytomegalovirus (CMV) reactivation in CMV\u2010seropositive patients. To evaluate the impact of LTV in matched sibling haematopoietic stem cell transplantation (HSCT) recipients, we retrospectively compared 72 matched sibling transplantation recipients receiving LTV with 134 controls. LTV significantly reduced 200\u2010day CMV viraemia incidence (5.6% vs. 33.3%, p<\/jats:italic>\u2009<\u20090.001). Multivariable analysis identified anti\u2010thymocyte globulin (ATG) use (p<\/jats:italic>\u2009=\u20090.005) and grade III\u2013IV acute graft\u2010versus\u2010host disease (aGVHD; p<\/jats:italic>\u2009<\u20090.001) as independent risk factors for CMV viraemia, while CMV serostatus did not significantly affect CMV viraemia (p<\/jats:italic>\u2009=\u20090.448). Stratification based on risk factors (ATG, grade III\u2013IV aGVHD) showed that LTV had a more significant effect on high\u2010risk patients compared to low\u2010risk patients. Also, LTV prophylaxis was associated with increased Epstein\u2013Barr virus (EBV) viraemia (13.9% vs. 1.4%, p<\/jats:italic>\u2009=\u20090.025) and higher CD20 monoclonal antibody utilization (11.1% vs. 1.4%, p<\/jats:italic>\u2009=\u20090.046). Long\u2010term survival remained similar between both groups. Results were validated in a second cohort from our centre. In conclusion, LTV prophylaxis significantly reduced CMV viraemia, especially in high\u2010risk patients (ATG\/grade III\u2013IV aGVHD). However, the LTV group showed an elevated risk of EBV\u2010related complications. Risk stratification\u2014rather than CMV serostatus alone\u2014should guide CMV prevention strategies in matched sibling HSCT. Larger clinical studies are needed for validation.<\/jats:p>","DOI":"10.1111\/bjh.70016","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T03:54:37Z","timestamp":1753156477000},"page":"965-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of letermovir prophylaxis in matched sibling donor haematopoietic stem cell transplantation: Selecting the appropriate population for optimal prophylactic therapy"],"prefix":"10.1111","volume":"207","author":[{"given":"Sisi","family":"Zhen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Hematopoietic Stem Cell Transplantation Center Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin P. R. 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