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However, these studies included very few patients with a diagnosis of high\u2010grade B\u2010cell lymphoma, not otherwise specified (HGBCL\u2010NOS) and it is unclear if outcomes are similar to those observed with more common LBCL histologies. Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, we identified 111 HGBCL\u2010NOS patients who received CAR\u2010T therapy. The cytokine release syndrome (CRS) rate was 74% (7.7% grade 3+), median onset was 4\u2009days (1\u201317) and immune effector cell\u2010associated neurotoxicity syndrome rate was 45.2% (22.6% grade 3+), median onset was 7\u2009days (1\u201317). At 2\u2009years post\u2010CAR\u2010T infusion, the probability of overall survival and progression\u2010free survival were 41.6% and 28.7% respectively. The 2\u2010year non\u2010relapse mortality and relapse\/progression were 3.1% (95% confidence interval [CI]: 0.6\u20137.6) and 68.1% (95% CI: 57.9\u201377.6) respectively. Our analysis illustrates that patients with HGBCL\u2010NOS represent a particularly difficult group to treat, even with CAR\u2010T therapy. We observed that one third of patients achieved a durable response; however, the overall results were less favourable, with lower overall response rate, overall survival and progression\u2010free survival as compared to published reports on LBCL.<\/jats:p>","DOI":"10.1111\/bjh.70020","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T09:59:03Z","timestamp":1753178343000},"page":"1011-1018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chimeric antigen receptor T\u2010cell therapy for high\u2010grade B\u2010cell lymphoma\n                    <scp>NOS<\/scp>"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-655X","authenticated-orcid":false,"given":"Nasheed M.","family":"Hossain","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology\u2010Cell Therapy and Transplant Program University of Pennsylvania\u2013Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Woo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Institute for Health and Society, Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinalben","family":"Patel","sequence":"additional","affiliation":[{"name":"CIBMTR\u00ae (Center for International Blood and Marrow Transplant Research), Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Lian","sequence":"additional","affiliation":[{"name":"CIBMTR\u00ae (Center for International Blood and Marrow Transplant Research), Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1128-0445","authenticated-orcid":false,"given":"Muhammad","family":"Bilal Abid","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston (UTHealth Houston)  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al Nughmush","sequence":"additional","affiliation":[{"name":"Department of Hematology, Stem Cell Transplant and Cellular Therapy, Oncology Centre King Faisal Specialist Hospital and Research Centre  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8771-947X","authenticated-orcid":false,"given":"Ulrike","family":"Bacher","sequence":"additional","affiliation":[{"name":"Department of Hematology Inselspital, University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Bi","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrukh K.","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"},{"name":"SSMC  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-4128","authenticated-orcid":false,"given":"Talal","family":"Hilal","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Husnain","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Banner University of Arizona, Medical Center  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Khimani","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Maziarz","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute\u2010Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6525-8844","authenticated-orcid":false,"given":"Dipenkumar","family":"Modi","sequence":"additional","affiliation":[{"name":"Karmanos Cancer Institute, Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Ram","sequence":"additional","affiliation":[{"name":"Hematology Department\u2010Tel Aviv (Sourasky) Medical Center, Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv\u2010Yafo Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rizzieri","sequence":"additional","affiliation":[{"name":"Novant Health Cancer Institute  Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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