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This study aimed to characterize pregnancy outcomes in the SCD mouse model with emphasis on analogous clinical correlates and biological contributors. As such, we identified worsened outcomes including reduced litter sizes (haemoglobin HbSS (SS)\u00a05.18\u2009\u00b1\u20091.25 embryos vs. haemoglobin HbAA (AA)\u00a06.86\u2009\u00b1\u20091.51**), fetal weight (SS 0.38\u2009\u00b1\u20090.16\u2009g vs. AA 0.49\u2009\u00b1\u20090.14\u2009g**), viability of embryos (SS 20.00% interquartile range (IQR) 33.33 vs. AA 100.00% IQR 0.0***) and maternal mortality (SS 7.14% (2\/28) vs. AA 0.00% (0\/27) odds ratio (OR)\u2009=\u20094.82\u2009ns). We further noted a significant reduction in vascular density and impaired uterine and umbilical artery blood flow within SCD placentae. Assessments of soluble growth factors revealed evidence of angiogenic dysregulation but maintained limited translational utility due to the multiparous nature of mouse pregnancy. These results serve as a cornerstone characterization of pregnancy outcomes in the SCD mouse model while highlighting the implications of placental vascular insufficiency. They further demonstrate both the utility and limitations of the model, emphasizing the need for continued clinical assessment.<\/jats:p>","DOI":"10.1111\/bjh.70024","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T02:04:06Z","timestamp":1753063446000},"page":"813-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterizing pregnancy outcomes in a humanized mouse model of sickle cell disease"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-0849","authenticated-orcid":false,"given":"Christopher","family":"Chambliss","sequence":"first","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Children's Healthcare of Atlanta Aflac Cancer and Blood Disorders Center  Atlanta Georgia 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