{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:42:12Z","timestamp":1788428532473,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Anthracycline\u2010containing chemotherapy is associated with cardiovascular diseases (CVDs). While knowledge regarding the extent of cardiotoxicity in adult patients with acute myeloid leukaemia (AML) is sparse, anthracyclines remain a key component in the treatment. To address this, 1379 adult AML patients treated with anthracycline\u2010containing chemotherapy between 2000 and 2020 were matched to 6895 comparators from the Danish background population and followed for a median of 11.8 and 12.8\u2009years respectively. The risk of congestive heart failure (CHF) was higher in AML patients compared to the comparators throughout the entire follow\u2010up period with adjusted hazard ratios (HRs) ranging from 15.0 (95% CI: 7.02\u201332.1) after 3\u2009months to 2.68 (95% CI: 1.67\u20134.30) after 15\u2009years. The risk of non\u2010CHF CVD was initially higher in AML patients (adjusted HR: 9.16 [95% CI: 6.61\u201312.7] after 3\u2009months) but converged to that of the comparators after approximately 10\u2009years. Among AML patients, increasing age and male sex were identified as risk factors of CHF and non\u2010CHF CVD. In summary, AML patients treated with anthracycline\u2010containing chemotherapy had an elevated risk of CVD, particularly during the first years after treatment initiation. Increased focus on early detection and cardioprotective strategies may help mitigate the harmful effects of anthracyclines in the future.<\/jats:p>","DOI":"10.1111\/bjh.70026","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T06:04:58Z","timestamp":1753164298000},"page":"1416-1424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiotoxicity in patients with acute myeloid leukaemia following anthracycline\u2010containing chemotherapy: A population\u2010based matched cohort study"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1492-092X","authenticated-orcid":false,"given":"Rikke Hedegaard","family":"Jensen","sequence":"first","affiliation":[{"name":"Center for Clinical Data Science, Department of Clinical Medicine Aalborg University and Research, Education, and Innovation, Aalborg University Hospital  Aalborg Denmark"},{"name":"Clinical 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