{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:21:38Z","timestamp":1792678898444,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016471","name":"Agios Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Evidence on the impact of anaemia and iron control on morbidity and mortality in \u03b2\u2010thalassaemia is limited to short\u2010term studies assessing spot measures. We conducted a retrospective longitudinal cohort study of 557 patients with \u03b2\u2010thalassaemia followed from diagnosis for a median of 38\u2009years. There was a significant association between the lifetime proportion spent on transfusion and thalassaemia\u2010related mortality (adjusted hazard ratios (HR) 0.987 for each 1\u2010percent increase,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014). In both patients with non\u2010transfusion\u2010dependent \u03b2\u2010thalassaemia (NTDT) and transfusion\u2010dependent \u03b2\u2010thalassaemia (TDT) (lifetime proportion on transfusion \u226470% and &gt;70%, respectively), there was a significant association between a lifetime anaemia and iron control index (LAICI) and mortality (NTDT: adjusted HR 0.916 for each 1\u2010point increase,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017; TDT: adjusted HR 0.672,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027). Survival was significantly lower in patients with suboptimal than optimal LAICI, defined based on international NTDT and TDT guidelines for anaemia and iron overload management (NTDT: adjusted HR 0.395,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046; TDT: adjusted HR 0.205,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.020 for optimal vs. suboptimal LAICI). Patients with optimal LAICI had significantly lower odds of cardiac (NTDT, TDT), vascular (TDT), hepatic (NTDT), endocrine morbidity (NTDT, TDT) and osteoporosis (NTDT). Optimal anaemia and iron control throughout the entire disease course are essential to reduce morbidity and mortality in patients with \u03b2\u2010thalassaemia.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70047","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:32:50Z","timestamp":1754026370000},"page":"1578-1588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of lifetime anaemia and iron control on outcomes in \u03b2\u2010thalassaemia: Data from the longitudinal de\u2010\n                    <scp>LIGHT<\/scp>\n                    study"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-903X","authenticated-orcid":false,"given":"Khaled M.","family":"Musallam","sequence":"first","affiliation":[{"name":"Center for Research on Rare Blood Disorders (CR\u2010RBD) and Thalassemia &amp; Sickle Cell Center, Burjeel Medical City  Abu Dhabi United Arab Emirates"},{"name":"Department of Public Health &amp; Epidemiology Khalifa University  Abu Dhabi United Arab Emirates"},{"name":"Division of Hematology\/Oncology, Department of Pediatrics Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1037-1767","authenticated-orcid":false,"given":"Angela","family":"Vitrano","sequence":"additional","affiliation":[{"name":"Campus of Haematology Franco and Piera Cutino, UOC Ematologia per le Malattie Rare Del Sangue e degli Organi Ematopoietici AOOR Villa Sofia\u2010V. Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Inzerillo","sequence":"additional","affiliation":[{"name":"Campus of Haematology Franco and Piera Cutino, UOC Ematologia per le Malattie Rare Del Sangue e degli Organi Ematopoietici AOOR Villa Sofia\u2010V. Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9568-9688","authenticated-orcid":false,"given":"Rosario","family":"Di Maggio","sequence":"additional","affiliation":[{"name":"Campus of Haematology Franco and Piera Cutino, UOC Ematologia per le Malattie Rare Del Sangue e degli Organi Ematopoietici AOOR Villa Sofia\u2010V. Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Barone","sequence":"additional","affiliation":[{"name":"Campus of Haematology Franco and Piera Cutino, UOC Ematologia per le Malattie Rare Del Sangue e degli Organi Ematopoietici AOOR Villa Sofia\u2010V. Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Giangreco","sequence":"additional","affiliation":[{"name":"Campus of Haematology Franco and Piera Cutino, UOC Ematologia per le Malattie Rare Del Sangue e degli Organi Ematopoietici AOOR Villa Sofia\u2010V. Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-0256","authenticated-orcid":false,"given":"Maria Concetta","family":"Renda","sequence":"additional","affiliation":[{"name":"Laboratorio Biobanca UOC Ematologia per le Malattie Rare Del Sangue e degli Organi Ematopoietici  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Fecarotta","sequence":"additional","affiliation":[{"name":"UOSD Diagnostica Molecolare Malattie Rare Ematologiche AOOR Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Troia","sequence":"additional","affiliation":[{"name":"UOSD Diagnostica Molecolare Malattie Rare Ematologiche AOOR Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5147-9547","authenticated-orcid":false,"given":"Antonino","family":"Giambona","sequence":"additional","affiliation":[{"name":"UOSD Diagnostica Molecolare Malattie Rare Ematologiche AOOR Villa Sofia\u2010Cervello  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovan Battista","family":"Ruffo","sequence":"additional","affiliation":[{"name":"UOSD Ematologia e Talassemia ARNAS Ospedali Civico Di Cristina Benfratelli  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2043-9630","authenticated-orcid":false,"given":"Efthymia","family":"Vlachaki","sequence":"additional","affiliation":[{"name":"Adults Thalaessemia Unit, Ippokratio Hospital, Aristotle University  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora M.","family":"Venou","sequence":"additional","affiliation":[{"name":"Adults Thalaessemia Unit, Ippokratio Hospital, Aristotle University  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-3308","authenticated-orcid":false,"given":"Paolo","family":"Ricchi","sequence":"additional","affiliation":[{"name":"UOSD Rare Red Blood Cell Disease, OncoHaematologic and PneumoThoracic Department \u201cCardarelli\u201d Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Ziello","sequence":"additional","affiliation":[{"name":"UOSD Rare Red Blood Cell Disease, OncoHaematologic and PneumoThoracic Department \u201cCardarelli\u201d Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Serra","sequence":"additional","affiliation":[{"name":"Centro Talassemia ed Emoglobinopatie UOC Medicina Interna PO \u201cVito Fazzi\u201d  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Colizzi","sequence":"additional","affiliation":[{"name":"Centro Talassemia ed Emoglobinopatie UOC Medicina Interna PO \u201cVito Fazzi\u201d  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-0382","authenticated-orcid":false,"given":"Filomena","family":"Longo","sequence":"additional","affiliation":[{"name":"SSD Day Hospital of Thalassaemia and Haemoglobinopathies, Department of Specialised Medicine AOU S. Anna of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Culcasi","sequence":"additional","affiliation":[{"name":"SSD Day Hospital of Thalassaemia and Haemoglobinopathies, Department of Specialised Medicine AOU S. Anna of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9601-900X","authenticated-orcid":false,"given":"Aurelio","family":"Maggio","sequence":"additional","affiliation":[{"name":"Campus of Haematology Franco and Piera Cutino, UOC Ematologia per le Malattie Rare Del Sangue e degli Organi Ematopoietici AOOR Villa Sofia\u2010V. 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