{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:26:04Z","timestamp":1787502364972,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    In the setting of haploidentical haematopoietic cell transplantation (HCT), post\u2010transplant cyclophosphamide (PTCy) has dramatically reduced the incidence of graft\u2010versus\u2010host disease (GVHD) and non\u2010relapse mortality. To further reduce GVHD incidence, the addition of antithymocyte globulin (ATG) to PTCy was evaluated in retrospective and non\u2010comparative prospective studies showing promising results. We conducted a large retrospective analysis of the European Society for Blood and Marrow Transplantation (EBMT) registry to evaluate this approach. We analysed haploHCT with peripheral blood stem cells performed for haematological malignancies between 2014 and 2021. GVHD prophylaxis included either PTCy alone or PTCy+ATG. Four thousand five hundred and nineteen patients were analysed in the PTCy only group versus 675 with PTCy+ATG. Median follow\u2010up was 29.80\u2009months. In univariate analysis, 2\u2010year GVHD\u2010free, relapse\u2010free survival (GRFS), relapse\u2010free survival (RFS), overall survival (OS), cumulative incidence of relapse, non\u2010relapse mortality (NRM) and chronic GvHD (cGVHD) were, respectively: 40.5% versus 37.5% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.098), 50.9% versus. 45.8% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015), 56.9% versus 52.5% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01), 24.2% versus 28.1% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.032), 25% versus 26.1% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.49) and 28.4% versus 18.5% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). aGVHD did not differ. After multivariable adjustment, OS and RFS were lower in the PTCy+ATG group: HR\u2009=\u20091.18 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037) and HR\u2009=\u20091.18 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027) and patients receiving PTCy+ATG had less cGVHD: HR\u2009=\u20090.68 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). In that retrospective analysis, the addition of ATG to PTCy for GVHD prophylaxis in haploHCT was associated with a reduction of cGVHD but also a worse OS and RFS.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70050","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:20:42Z","timestamp":1754558442000},"page":"1529-1537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of the addition of antithymocyte globulin to post\u2010transplantation cyclophosphamide in haploidentical transplantation with peripheral blood compared to post\u2010transplantation cyclophosphamide alone: A retrospective study on behalf of the Cellular Therapy and Immunobiology Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-9519","authenticated-orcid":false,"given":"Antoine","family":"Capes","sequence":"first","affiliation":[{"name":"H\u00f4pital Saint Antoine, AP\u2010HP, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarl E.","family":"Mooyaart","sequence":"additional","affiliation":[{"name":"EBMT Statistical Unit  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Transplantation and Cellular Immunotherapy, Department of Hematology, Institut Paoli Calmettes, Management Sport Cancer Lab Aix Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bramanti","sequence":"additional","affiliation":[{"name":"Istituto Clinico Humanitas  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Kwon","sequence":"additional","affiliation":[{"name":"Hospital Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8536-7781","authenticated-orcid":false,"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Antoine, AP\u2010HP, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-5581","authenticated-orcid":false,"given":"Patrice","family":"Chevallier","sequence":"additional","affiliation":[{"name":"CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vydra","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Rem\u00e9nyi","sequence":"additional","affiliation":[{"name":"D\u00e9l\u2010pesti Centrumk\u00f3rh\u00e1z  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-2868","authenticated-orcid":false,"given":"Edouard","family":"Forcade","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Hopital Haut\u2010Leveque  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-5596","authenticated-orcid":false,"given":"Luc\u00eda","family":"L\u00f3pez Corral","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca\u2010IBSAL  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija","family":"It\u00e4l\u00e4\u2010Remes","sequence":"additional","affiliation":[{"name":"Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Program, Department of Internal Medicine American University of Beirut, Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-8140","authenticated-orcid":false,"given":"Enrico","family":"Derenzini","sequence":"additional","affiliation":[{"name":"European Institute of Oncology  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorinde D.","family":"Hoogenboom","sequence":"additional","affiliation":[{"name":"EBMT Leiden Study Unit  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Kuball","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht  Utrecht The 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