{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:18:35Z","timestamp":1792919915042,"version":"4.5.0"},"reference-count":68,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    T\u2010cell lymphoblastic lymphoma (T\u2010LBL) is the second most common subtype of non\u2010Hodgkin lymphoma (NHL) in children and adolescents. T\u2010LBL shares considerable biological and clinical features with T\u2010cell acute lymphoblastic leukaemia (T\u2010ALL). The two entities are clinically distinguished by the extent of bone marrow (BM) involvement at diagnosis, with T\u2010ALL defined by \u226525% blasts in the BM. Although the WHO classifies T\u2010LBL and T\u2010ALL as a single entity, emerging data suggest relevant clinical and molecular differences. This review focuses on T\u2010LBL in paediatric patients, summarizing current knowledge on its clinical presentation, immunophenotype and molecular landscape. We further explore age\u2010associated genomic patterns, recurrent mutations and chromosomal aberrations, with a particular focus on their prognostic relevance. Notably, recent studies have identified\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    \u2010fusions as exclusive to paediatric T\u2010LBL, absent in T\u2010ALL, and are associated with an increased risk of relapse. We highlight the limited applicability of measurable residual disease, lack of harmonized risk stratification and the need for T\u2010LBL\u2010specific treatment adaptations. Ultimately, this review emphasizes the urgent need for biologically informed, risk\u2010adapted treatment strategies and collaborative research efforts to advance care and outcomes of paediatric patients with T\u2010LBL.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70053","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:26:48Z","timestamp":1755149208000},"page":"1213-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["T\u2010cell lymphoblastic lymphoma in children, adolescents and young adults"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0864-1585","authenticated-orcid":false,"given":"Marcel","family":"te Vrugt","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Non\u2010Hodgkin Lymphoma Berlin\u2010Frankfurt\u2010Muenster Study Center University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Newman","sequence":"additional","affiliation":[{"name":"Division of Oncology The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Teachey","sequence":"additional","affiliation":[{"name":"Division of Oncology The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-829X","authenticated-orcid":false,"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology and Non\u2010Hodgkin Lymphoma Berlin\u2010Frankfurt\u2010Muenster Study Center University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05735.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148809"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092075"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-051672"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022018653"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.542"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07320.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0000000000000247"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14319"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-024-03819-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0136-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2418"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31302"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001822"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-3994"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7203"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30401"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21518"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.030809"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12042"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004334"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283623c61"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.312"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-474148"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005381"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7661"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024025307"},{"issue":"7","key":"e_1_2_11_31_1","article-title":"NOTCH1 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