{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:50:27Z","timestamp":1789498227129,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG\u201025024"],"award-info":[{"award-number":["IG\u201025024"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Leukaemic cells from hairy cell leukaemia (HCL) secrete a soluble form of the interleukin\u20102 receptor (sIL\u20102R) which is measurable in serum. Previous evidence suggested that sIL\u20102R may correlate well with tumour burden and demonstrated a reduction in sIL\u20102R levels after therapy with recombinant interferon\u2010\u03b12. We evaluated the role of sIL\u20102R as a new prognostic factor and as a tool for disease monitoring. sIL\u20102R correlated well with other markers of neoplastic bulk and markedly decreased after treatment, with lower levels achieved in patients reaching complete remission (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) or negative minimal residual disease (MRD, <jats:italic>p<\/jats:italic>\u2009=\u20090.034). Post\u2010treatment levels \u2264827 kU\/L were strongly predictive of longer time to next treatment (TTNT) (median NR vs. 4.87\u2009years; hazard ratio [HR]: 0.10; 95% confidence interval [CI]: 0.02\u20130.24; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and higher 5\u2010 and 10\u2010year TTNT rates (5\u2010year: 93% vs. 45%; 10\u2010year: 83% vs. 11%). Furthermore, a \u226550% increase in sIL\u20102R levels over any 1\u2010year interval during follow\u2010up predicted impending relapse. In a context where patients with HCL are expected to achieve a life expectancy comparable to that of the general population, sIL\u20102R has the potential to serve as a non\u2010invasive tool alongside MRD to predict relapse and to identify those patients who may fail to derive the most benefit from current treatments.<\/jats:p>","DOI":"10.1111\/bjh.70059","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T05:15:10Z","timestamp":1753852510000},"page":"1357-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum soluble interleukin\u20102 receptor levels in hairy cell leukaemia as a marker of tumour burden with prognostic value and as a tool for disease monitoring"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-2573","authenticated-orcid":false,"given":"Francesco","family":"Angotzi","sequence":"first","affiliation":[{"name":"Hematology Unit, Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cellini","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Danesin","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Medicine University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Zoletto","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Medicine University of Padova  Padova 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