{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:40:55Z","timestamp":1783687255501,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100024731","name":"AABB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPOC21\u201010\/L2590"],"award-info":[{"award-number":["PPOC21\u201010\/L2590"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPOC23\u201009\/L2753"],"award-info":[{"award-number":["PPOC23\u201009\/L2753"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Many blood establishments worldwide monitor serum ferritin alongside mandatory haemoglobin (Hb) screening to better protect donors from iron deficiency and anaemia. However, the relationship between ferritin and Hb, and the ferritin level that indicates iron deficiency, remains unclear. Whole blood donation results in significant iron loss, and repeated donations can deplete iron stores. This study analysed over 1 million whole\u2010blood donations from four countries to explore the association between Hb change and ferritin levels. Hb change was defined relative to a donor's initial Hb level. A consistent two\u2010phase relationship emerged: At low ferritin levels, Hb change is linearly associated with log ferritin; above a certain threshold, this association disappears as donors recover their reference Hb. The transition point and slope of this association differ by population. These results suggest that ferritin thresholds for identifying limited Hb recovery are not universal but population\u2010specific, influenced by biological and procedural differences, including ferritin assay variability. While the overall pattern is consistent, the absence of standardized procedures and assays limits the ability to define global ferritin thresholds for donor care. This underscores the importance of localized approaches to ferritin\u2010based donor management and the need for harmonized methodologies across blood services.<\/jats:p>","DOI":"10.1111\/bjh.70066","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T06:09:26Z","timestamp":1754546966000},"page":"1096-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Blood donor populations reveal a clear association between ferritin and change in haemoglobin levels"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-2179","authenticated-orcid":false,"given":"Amber","family":"Meulenbeld","sequence":"first","affiliation":[{"name":"Donor Health, Department of Research Sanquin Blood Supply Foundation  Amsterdam The Netherlands"},{"name":"Department of Public and Occupational Health and the Amsterdam Public Health Research Institute Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa V.","family":"Turkulainen","sequence":"additional","affiliation":[{"name":"Research and Development Finnish Red Cross Blood Service  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Population and Global Health McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart R.","family":"Pothast","sequence":"additional","affiliation":[{"name":"Transfusion Technology Assessment, Department of Research Sanquin Blood Supply Foundation  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchao","family":"Qi","sequence":"additional","affiliation":[{"name":"BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care University of Cambridge  Cambridge UK"},{"name":"NIHR Blood and Transplant 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Alton","family":"Russell","sequence":"additional","affiliation":[{"name":"School of Population and Global Health McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Arvas","sequence":"additional","affiliation":[{"name":"Research and Development Finnish Red Cross Blood Service  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart P.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Transfusion Technology Assessment, Department of Research Sanquin Blood Supply Foundation  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16688"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14133"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15906"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15133"},{"key":"e_1_2_10_6_1","volume-title":"WHO Guideline on Use of Ferritin Concentrations to Assess Iron Status in Individuals and Populations","author":"WHO","year":"2020"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01085\u20107"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13377"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52429"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/AJCN.117.155960"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.GASTRO.2020.06.046"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010020\u201001631\u2010y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(24)00103\u20100"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13515"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12856"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)31928\u20101"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(19)30106\u20101"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008264\u20105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(21)00168\u2010X"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102021\u20101139"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM\u20102012\u20100129"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOLOGICALS.2010.02.007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/43.9.1582"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvac099"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.304"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102023\u20100711"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186662"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17085"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T02:56:18Z","timestamp":1757991378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/bjh.70066"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70066","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"2025-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}