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Frailty was assessed in all patients at the first consultation, at transplant admission and on day +100. Quality of life (QoL) was measured using the EuroQol (EQ\u20105D\u20105L) questionnaire. At the first consultation, 23.8% were fit, 57.6% pre\u2010frail and 18.6% frail. Frailty was associated with advanced disease stage, reduced Karnofsky Performance Status and older age. At HCT admission, 32.3% of patients showed changes in frailty status, confirming its dynamic nature. Frail patients had higher readmission rates (14.7%) and significantly lower QoL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to others. Although differences in non\u2010relapsed mortality (NRM) were not statistically significant, frail and pre\u2010frail patients showed higher 1\u2010year NRM (4.8% and 3.4%) compared to fit patients (0%). By day +100, 33.6% were fit, 55.9% pre\u2010frail and 8.2% frail, with frail patients continuing to report poorer QoL. In conclusion, the HCT Frailty Scale is a valuable tool for identifying and monitoring frailty in MM patients undergoing auto\u2010HCT. As frailty status evolves over time, ongoing assessment is essential to guide personalized care, reduce complications and improve outcomes and QoL.<\/jats:p>","DOI":"10.1111\/bjh.70068","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T02:41:05Z","timestamp":1755052865000},"page":"1504-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Frailty dynamics and their impact on <scp>QoL<\/scp> in patients undergoing autologous <scp>HCT<\/scp> for multiple myeloma: Results from a multicentre <scp>GETH<\/scp>\u2010<scp>TC<\/scp> study"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0706-9046","authenticated-orcid":false,"given":"Carles","family":"Tolosa\u2010Ridao","sequence":"first","affiliation":[{"name":"Servicio Hematolog\u00eda Hospital Universitari M\u00fatua Terrassa  Barcelona Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica Baile","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Complejo Asistencial Universitario de Salamanca\/IBSAL  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Acera","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Complejo Asistencial Universitario de Salamanca\/IBSAL  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fox","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Mar","family":"P\u00e9rez Artigas","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Hospital \u00c1lvaro Cunqueiro  Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Carmen","family":"Quintela Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital \u00c1lvaro Cunqueiro  Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s S\u00e1nchez","family":"Salinas","sequence":"additional","affiliation":[{"name":"Unidad de Trasplante de Progenitores Hematopoy\u00e9ticos H.C.U. 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